Brain Tumor SPORE Grant

描述（由申请人提供）： 该应用程序代表了来自美国的跨学科研究人员团队的努力， UCSF癌症中心的神经肿瘤学计划，以应用他们的知识和专业知识， 转化研究集中在脑肿瘤上。该提案的核心是四个转化研究项目，每个项目都由应用和基础研究人员驱动，每个项目都旨在创造可能用于治疗人类脑肿瘤的新工具和疗法。项目一的重点是使用人口科学来寻找神经胶质瘤患者生存的重要因素。项目二的重点是使用先进的光谱技术，以提高诊断和手术切除肿瘤。项目三的重点是开发脂质体药物递送，以改善胶质瘤的治疗，而项目四旨在表征信号转导级联作为指导胶质瘤治疗的一种手段。该提案还包括职业发展研究计划，发展研究计划和2个核心的支持机制，将支持所提出的工作的各个方面。每个项目都借鉴了研究人员在脑肿瘤领域的丰富经验，以及UCSF神经外科系和UCSF脑肿瘤研究中心在转化研究方面的悠久历史。这些项目将通过合作得到进一步加强 研究人员和其他科学家在加州大学旧金山分校癌症中心，（特别是在项目三的情况下），与科学家参与现有的加州大学旧金山分校乳腺肿瘤孢子。最后，作为美国脑肿瘤临床试验的领先中心，神经外科部门已经建立的基础设施将使重要科学突破的快速临床转化成为可能。 UCSF脑肿瘤孢子由Mitchel Berger博士领导，他是神经外科和转化脑肿瘤研究的全国公认领导者。本提案的临床共同主要研究者是Michael Prados，MD。Prados博士是北美脑肿瘤联盟的负责人，也是儿科脑肿瘤联盟的首席研究员。他是临床试验开发和实施方面公认的领导者，非常适合将我们的发现带到临床。临床专业知识，沿着在UCSF强大的实验室为基础的研究气候，表明拟议的工作将导致脑肿瘤治疗的重大进展。

DESCRIPTION (provided by applicant): This application represents the efforts of interdisciplinary teams of investigators from the Neuro-Oncology Program of the UCSF Cancer Center to apply their knowledge and expertise to translational research focused on brain tumors. The heart of the proposal is four translational research projects, each driven by pairs of applied and basic researchers, and each intended to create novel tools and therapies potentially useful in the treatment of human brain tumors. Project One focuses on the use of population science to find factors important in glioma patient survival. Project Two focuses on the use of sophisticated spectroscopic techniques to improve diagnosis and surgical resection of tumors. Project Three focuses on the development of liposomal drug delivery to improve the therapy of gliomas, while Project Four intends to characterize signal transduction cascades as a means of guiding glioma therapy. The proposal also includes support mechanisms for Career Development Research Programs, Developmental Research Programs, and 2 Cores that will support all aspects of the work proposed. Each project draws on the extensive experience of the investigators in the brain tumor field and on the long history of the UCSF Department of Neurosurgery and the UCSF Brain Tumor Research Center in translational research. The projects will be additionally strengthened by collaborations between researchers and other scientists in the UCSF Cancer Center, and (particularly in the case of Project Three), with scientists involved with the existing UCSF Breast Tumor SPORE. Finally, as a leading center of brain tumor clinical trials in America, an infrastructure already in place in the Department of Neurosurgery will allow the rapid clinical translation of important scientific breakthroughs. The UCSF Brain Tumor SPORE is led by Mitchel Berger, MD, a nationally recognized leader in neurosurgery and translational brain tumor research. The clinical Co-PI of this proposal is Michael Prados, MD. Dr. Prados is head of the North American Brain Tumor Consortium, and a Principal Investigator of the Pediatric Brain Tumor Consortium. He is a recognized leader in the development and implementation of clinical trials, and is ideally suited to carry our findings to the clinic. The clinical expertise, along with the strong laboratory-based research climate at UCSF, suggest that the work proposed will lead to significant progress in the treatment of brain tumors.