THE JACKSON LABORATORY REPOSITORY

描述（由申请人提供）： 生物医学研究界将杰克逊实验室（TJL）视为用于高度专业化研究应用的独特遗传定义小鼠的领先资源。超过2700个菌株的集合包括近800个菌株，这些菌株以低但稳定的数量分布。需求是恒定的，活的育种菌落，而不是冷冻保存的种质，是最经济的维持手段。这些菌株被分发给700个机构的近1000名研究人员。构成TJL低需求菌株库的菌落现在被安置在16个不同的小鼠房间中，其中一些没有无菌供应交付的能力。物理上分散的资源使得难以实施一致的管理模式，以确保以合理的成本和在合理的时间内将小鼠交付给要求它们的研究者。一个为期一年的规划小组建议将菌株收集合并到一个单一的专用杰克逊实验室储存库中，在该储存库中可以采用最佳管理实践，储存库小鼠可以在提供无菌材料的高级别屏障设施中饲养。申请资金用于翻修两个现有的动物房，每个2191英尺（2），以提升屏障状态，并为每个房间购买一个空气淋浴器，20个HEPA过滤，通风更换站和两个层流罩。

DESCRIPTION (provided by applicant): The biomedical research community regards The Jackson Laboratory (TJL) as a leading resource for unique genetically defined mice for use in highly specialized research applications. The collection of over 2700 strains includes nearly 800 strains that are distributed in low but steady numbers. The demand is constant enough that live breeding colonies, rather than cryopreserved germplasm, is the most economical means of maintenance. These strains are distributed to nearly 1000 investigators at 700 institutions. The colonies that comprise TJL's repository of low-demand strains are now housed in 16 different mouse rooms, some of which do not have the capability for sterile supply delivery. The physically dispersed resources make it difficult to implement consistent management paradigms that will ensure mice are delivered to investigators who request them at reasonable cost and within a reasonable period of time. A year-long planning group has recommended that the collections of strains be consolidated into a single, dedicated Jackson Laboratory Repository in which optimal management practices can be employed and Repository mice can be maintained in a high-level barrier facility supplied with sterile materials. Funds are requested to renovate two existing animal rooms of 2191 ft(2) each to upgrade the barrier status and to purchase an air shower for each room, 20 HEPA-filtered, ventilated changing stations, and two laminar flow hoods.