Stadardized Assesment of Swallowing Impairment

描述(申请人提供)：候选人对这一奖励机制的兴趣源于她的职业生涯，其中包括将有意义的以患者为导向的研究整合到评估和治疗吞咽障碍患者的临床实践中。应聘者的最终职业目标是独立研究和定义成人慢性肺部疾病患者的吞咽功能障碍；然而，目前还没有经过验证或可靠的测量工具来检测和量化吞咽障碍。作为未来慢性肺病患者吞咽独立研究的初步步骤，将需要开发一种吞咽损害测量工具，用于改良的吞钡评估。这一工具(MBSImP)将具有临床意义、实际实施、可靠的评分，并对观察到的渴望的存在以及对健康和生活质量的外部指标敏感。该奖项的结构提供了一种工具，以促进这些短期和长期目标的实现，并促进候选人成功地从临床卓越和早期临床科学家发展为独立的临床研究人员。在研究计划中提出了一种复杂的缩减和聚合策略，需要应用多元统计分析、测量理论和量表开发、因素分析和潜变量建模的知识。这位候选人在她的职业规划中包括了一名导师和外部顾问来监督她的综合课程，其中包括教学课程和统计设计、测量和因子分析领域的独立研究。要实现应聘者既定的职业目标，需要全面了解上呼吸道的大体解剖学、生理学和病理生理学。作为吞咽和吞咽障碍领域的临床科学家的高级能力将需要了解和应用重叠吞咽生理学。虽然Martin-Harris博士在口咽吞咽动力学和肺功能的临床研究中表现出很强的临床熟练程度，但她对颈、胸和远端食道的结构和功能缺乏了解。肺部疾病患者和研究计划中的预期患者经常合并口咽和食道吞咽障碍。因此，候选人包括高级头部、颈部和胸部解剖、头部和颈部手术旋转方面的教学课程，以及与她的主要导师、世界著名的食道吞咽障碍临床医生和研究人员的独立研究。

DESCRIPTION (provided by applicant): The origin of the candidate's interest in this award mechanism stems from her career pathway that has included the integration of meaningful patient-oriented research into the clinical practice of evaluating and treating patients with swallowing disorders. The ultimate career goal of the candidate is to independently study and define functional swallowing impairment in adult patients with chronic pulmonary disease; however, there exists no validated or reliable measurement tool that permits the detection and quantification of swallowing impairment. A preliminary step toward the future pathway of independent swallowing research of patients with chronic pulmonary disease will require the development of a swallowing impairment measurement tool to be used during the modified barium swallowing evaluation. This tool (the MBSImP) will be clinically meaningful, practically implemented, reliably scored and sensitive to the presence of observed aspiration and to external indicators of health and quality of life. The structure of this award provides a vehicle to facilitate achievement of these short-term and long-term goals, and to the candidate's successful progression from clinical excellence and early stage clinical scientist to an independent clinical researcher. A complex reduction and aggregation strategy is proposed in the research plan that requires knowledge of applied multivariate statistical analyses, measurement theory and scale development, factor analysis and latent variable modeling. The candidate has included a mentor and external advisor to oversee a comprehensive curriculum in her Career Plan that includes didactic coursework and independent studies in the areas of statistical design, measurement, and factor analysis. Achievement of the candidate's stated career goals will require comprehensive understanding of the gross anatomy, physiology and pathophysiology of the upper aerodigestive tract in its entirety. Advanced competency as a clinical scientist in the area of swallowing and swallowing disorders will require understanding and application of overlapping swallowing physiology. While Dr. Martin-Harris demonstrates strong clinical proficiency in the clinical study of oropharyngeal swallowing dynamics and pulmonary function, she has insufficient knowledge of cervical, thoracic and distal esophageal structure and function. Patients with pulmonary disease and the prospective patients to be studied in the research plan often present with coexisting oropharyngeal and esophageal swallowing disorders. Therefore, the Candidate has included didactic coursework in advanced head, neck and chest anatomy, head and neck surgical rotations, and independent studies with her primary mentor, a world renowned clinician and researcher of esophageal swallowing disorders.