VASCULAR BIOLOGY IN CANCER

描述（由申请人提供）：博士后研究员提供直接的研究经验，责任和培训，在六个独立实验室单位之一的教师负责人的监督下进行基础和适用的血管生物学的调查发现。 正在探索内皮细胞分子细胞生物学和相关分子和系统，以描绘与肿瘤环境相关时由血管发育赋予的基因表达模式。 这些包括可能与癌症的血管生物学有关的基因表达模式和细胞信号通路的调查。 由受训者进行的研究包括但不限于发现肿瘤中血管内皮的体内基因表达的新模式，血管生成的控制，影响内皮细胞生物学的细胞信号传导事件，在肿瘤微血管环境中调节的血栓形成和炎症级联反应，设计蛋白质和衍生物分子以抑制肿瘤相关的血管生成，以及尝试开发对肿瘤环境有选择性的血管消融分子。 学员与他们的导师谁是全职研究人员立即密切联系。 每周的研讨会和数据审查由每个教师与他们的小组进行。 医学博士，博士M.D.博士征聘候选人并为独立调查职业做好准备。

DESCRIPTION (provided by applicant): Postdoctoral research fellows are provided direct research experience, responsibility, and training in conduct of investigative discovery of fundamental and applicable vascular biology under supervision of a faculty head of one of the six independent laboratory units. Endothelial cell molecular cell biology and related molecules and systems are being explored to delineate patterns of gene expression imparted by vascular development when in association with the tumor environment. These include survey of gene expression patterns and cell signaling pathways that may be implicated in the vascular biology of cancer. Investigations conducted by trainees include, but are not limited to, discovery of novel patterns of gene expression by the vascular endothelium in vivo in tumors, control of angiogenesis, cell signaling events influencing endothelial cell biology, the thrombogenic and inflammatory cascades as regulated in the tumor microvasculature environment, the design of proteins and derivative molecules to inhibit tumor associated angiogenesis as well as attempts to development vascular ablative molecules selective for the tumor environment. Trainees are in immediate close association with their mentors who are full-time research faculty. Weekly seminars and review of data are conducted by each of the faculty members with their group. M.D., Ph.D. and M.D./Ph.D. candidates are recruited and prepared for an independent investigative career.