"Comparative Stress Analysis of Hip Dysplasia"

描述（由申请方提供）：本研究将检查正常和发育不良患者的髋关节生物力学，特别关注“传统”发育不良患者与发育不良髋臼后倾患者。将使用患者特定有限元模型预测三个患者组（正常、传统发育不良、后倾发育不良）的接触面积、最大软骨应力和最大骨应力及其位置。本研究的基本原理源于髋臼发育不良可能是髋关节过早骨关节炎的主要原因;然而，与不同类型发育不良相关的几何形状改变与关节中产生的应力之间的确切关系尚不清楚。研究髋臼发育不良和髋关节骨关节炎发展之间关系的文献是矛盾的。本研究的总体目标是阐明在模拟单腿站立和爬楼梯过程中，正常髋关节、“传统”发育不良髋关节和髋臼后倾发育不良髋关节患者髋关节载荷和应力的生物力学差异。

DESCRIPTION (provided by applicant): This study will examine the biomechanics of the hip in normal and dysplastic patients, specifically focusing on patients with "traditional" dysplasia versus those with a dysplastic retroverted acetabulum. Patient-specific finite element models will be used to predict contact areas, maximum cartilage stresses and maximum bone stresses and their locations for three patient groups (normal, traditional dysplastic, retroverted dysplastic). The rationale for this study stems from the fact that acetabular dysplasia may be the leading cause of premature osteoarthritis of the hip; however, the exact relationships between the altered geometries associated with different types of dysplasia and the resulting stresses in the joint are poorly understood. The literature that has examined the relationships between acetabular dysplasia and development of hip osteoarthritis is contradictory. The overall objective of this study is to elucidate the biomechanical differences in hip joint loading and stresses in patients with normal hips, "traditional" dysplastic hips and hips with dysplasia characterized by retroversion of the acetabulum during simulated single-leg stance and stair climbing.