ACTIVITY 2: ENHANCEMENT OF INSTITUTIONAL RESEARCH CAPACITY IN MOLECULAR GENETICS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。由于它们之间的密切互动和互补的基础设施，我们建议将先前在波多黎各大学医学校园设立的分子生物学核心设施和人类分子遗传学研究所(UPR-MSC)融合为一个单一的核心设施，称为分子遗传学核心设施(MGCF)。该设施的目标是通过支持具有强大的分子生物学和分子遗传学组件的基础和临床项目来增强我们的机构生物医学研究能力。为实现这一目标，我们提出了以下具体目标。1.提供必要的基础设施，以维持目前在MSC进行的分子遗传学研究，特别是那些处理健康差距的项目。2.通过培养分子生物学和遗传学的研究生和本科生，增加分子生物学和遗传学研究项目的临界量。3.继续提供可用于人类基因组分析的分子遗传学新方法，向教职员工提供分子遗传学方面的专门培训。4.开发人类和其他来源的核酸的基因分型和/或DNA测序系统。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Because of their close interaction and complementing infrastructures, we proposed that the Molecular Biology Core Facility and the Human Molecular Genetics Unit previously established at the University of Puerto Rico Medical Sciences Campus (UPR-MSC) be fused into a single core facility called the Molecular Genetics Core Facility (MGCF). The goal of this facility was to enhance our institutional biomedical research capability by supporting basic and clinically oriented projects with strong molecular biology and molecular genetics components. To fulfill this goal, we proposed the following specific aims. 1. To provide the infrastructure necessary to sustain the research currently conducted in molecular genetics at the MSC especially those projects that address health disparities. 2. To increase the critical mass of research projects in molecular biology and genetics conducted at the MSC by training graduate and undergraduate students in these areas. 3. To continue to make available new methodologies in molecular genetics that can be used for analysis of the human genome by providing specialized training in molecular genetics to faculty and staff members. 4. To develop a system for genotyping and/or DNA sequencing of nucleic acids derived from humans and other sources.