Functional analysis of breast cancer susceptibility regions

最近的研究已经确定了人类基因组中DNA序列变异与乳腺癌风险增加相关的区域。其中几个区域不包含任何已知基因，这表明调控DNA序列是相关风险的罪魁祸首。这项提议的目的是识别和表征这些DNA序列。了解这些区域的序列变异是如何导致乳腺癌的，将为治疗提供新的途径。

Recent studies have identified regions within the human genome in which DNA sequence variations are associated with an increased risk of breast cancer. Several of these regions do not contain any known genes, suggesting that regulatory DNA sequences are responsible for the associated risk. The aim of this proposal is to identify and characterise these DNA sequences. Understanding how sequences variations in these regions contribute to breast cancer will provide novel avenues for therapy.