THE ADAPT HYPERTENSION STUDY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。与白人相比，高血压在非洲裔美国人中更常见，也更严重。在一项随机试验中，阻止高血压的饮食方法（DASH）饮食模式被证明可以降低高血压，并且对非洲裔美国人的影响最大。然而，当转化为真实的世界时，DASH模式的有效性研究显示，对非洲裔美国人只有适度的降压益处，特别是对非洲裔美国妇女没有益处。使用形成性分析的原则，我们已经开发出一种改良的DASH饮食模式干预，预计将在文化上适合非洲裔美国人。本研究的主要目的是进行一项随机对照试验，以确定与常规护理对照组相比，改良的DASH饮食模式在降低高血压前期或I期高血压的非洲裔美国人队列血压方面的有效性。我们假设，与常规护理对照组相比，在一组高血压前期至I期高血压的非裔美国人中，使用文化上适当的DASH饮食干预将实现更大的血压降低。主要结果是6个月时收缩压和舒张压的变化。次要结果包括水果，蔬菜，乳制品和脂肪摄入量的变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypertension is both more common and more severe in African-Americans compared with Whites. The Dietary Approaches to Stop Hypertension (DASH) dietary pattern was proven to reduce hypertension in a randomized trial, and the effect was greatest for African-Americans. However, when translated into the real world, an effectiveness study of the DASH pattern revealed only modest blood pressure lowering benefit for African-Americans and no benefit for African American women, in particular. Using principles of formative analysis, we have developed a modified DASH dietary pattern intervention that is expected to be culturally appropriate for African-Americans. The primary aim for this study is to conduct a randomized, controlled trial to determine the effectiveness of the modified DASH dietary pattern in reducing blood pressure for a cohort of African-Americans with pre-hypertension or stage I hypertension compared to a usual care control group. We hypothesize that greater blood pressure reduction will be achieved using a culturally appropriate DASH diet intervention in a group of African-Americans with prehypertension to stage I hypertension compared to a usual care control group. Primary outcomes are change in systolic and diastolic BP at 6 months. Secondary outcomes include changes in fruit, vegetable, dairy, and fat intake.