Epidemiology of Prescription Drug Abuse in the United States

描述（由申请人提供）： 向NIDA申请R03是对RFA-DA-05 - 005《NESARC和NSPY数据集的二次分析》的回应;我们建议对两个国家数据集进行二次分析，以检查以下趋势：（1）处方药非医疗使用（NMPD）和处方药使用障碍（PDUD）的患病率和相关性，（2）伴随NMPD和酒精使用的患病率和相关性，包括酒精使用障碍（AUD），和（3）1991 - 1992年和2001 - 2002年之间美国开始NMPD和其他药物使用的年龄。几类受控物质的非医疗用途（例如，抗焦虑药、阿片类镇痛药、镇静剂/催眠药和兴奋剂）在过去十年中在美国增加。虽然有许多潜在的后果与伴随的NMPD和酒精使用有关，但这两种物质使用行为之间的关联在全国人群研究中很少受到关注。为了弥补这些差距，我们建议对1991 - 1992年全国纵向酒精流行病学调查和2001 - 2002年全国酒精及相关疾病流行病学调查进行二次分析;每一个都有大约43个具有全国代表性的大样本，将使用能够在进行多变量分析时考虑复杂样本设计的统计软件包分析NLAES和NESARC数据集。拟议项目的具体目标是评估：（1）1991 - 1992年和2001 - 2002年期间NMPD和PDUD的流行趋势和相关因素;（2）1991 - 1992年和2001 - 2002年期间（a）NMPD和酒精使用的伴随因素和（B）PDUD和AUD的伴随因素的流行趋势和相关因素;（3）1991 - 1992年和2001 - 2002年开始使用NMPD和其他药物的年龄趋势。本研究的结果将增强我们对处方药非医疗使用、处方药使用障碍和新出现的物质使用形式的了解。它将有助于查明药物滥用的危险因素。最重要的是，这些发现将为预防、评估和治疗处方药滥用提供指导。

DESCRIPTION (provided by applicant): This R03 application to NIDA is in response to RFA-DA-05-005, Secondary Analysis of the NESARC and NSPY Datasets; we propose a secondary analysis of two national datasets to examine the trends in (1) the prevalence and correlates of nonmedical use of prescription drugs (NMPD) and prescription drug use disorders (PDUD), (2) the prevalence and correlates of concomitant NMPD and alcohol use, including alcohol use disorders (AUD), and (3) age of initiation of NMPD and other drug use in the U.S. between 1991- 1992 and 2001-2002. The nonmedical use of several classes of controlled substances (e.g., anxiolytics, opioid analgesics, sedative/hypnotics, and stimulants) has increased in the past decade in the U.S. While there are many potential consequences associated with concomitant NMPD and alcohol use, the association between these two substance use behaviors has received very little attention in national population-based research. In order to address these gaps, we propose to conduct a secondary analysis of the 1991-1992 National Longitudinal Alcohol Epidemiogical Survey (NLAES) and the 2001-2002 National Epidemiology Survey on Alcohol and Related Conditions (NESARC); each feature large nationally representative samples of approximately 43,000 adults 18 years of age and older in the U.S. The NLAES and NESARC datasets will be analyzed using a statistical software package capable of taking a complex sample design into account while performing multivariate analyses. The specific aims of the proposed project are to assess: (1) trends in the prevalence and correlates of NMPD and PDUD between 1991-1992 and 2001-2002; (2) trends in prevalence and correlates of (a) concomitant NMPD and alcohol use and (b) concomitant PDUD and AUD between 1991-1992 and 2001-2002; and (3) trends in age of initiation of NMPD and other drug use between 1991-1992 and 2001-2002. The findings of this study will enhance our understanding of nonmedical use of prescription drugs, prescription drug use disorders and emerging forms of substance use. It will help identify risk factors for substance abuse. Most importantly, the findings will provide guidance for the prevention, assessment, and treatment of prescription drug abuse.