Effect Of Diet and Other Early Exposures on Child Health

饮食和其他早期接触可能会影响儿童发育和几种慢性病的风险，但还需要进一步的研究。 这个“包罗万象”项目中描述的目前的研究包括两个子项目：第一，研究怀孕期间牙科手术和治疗引起的继发暴露的影响；第二，一组相互关联的研究，都与怀孕期间女性的激素水平与种族和后代隐睾症等因素有关，这些因素是睾丸生殖细胞肿瘤的风险因素。 对怀孕期间牙科手术和治疗引起的继发性暴露的影响的研究基于雅芳父母和儿童纵向研究的数据。有8,251名妇女的牙科病史数据，检查的结果是出生体重、早产和儿童的沟通发展。 关于怀孕期间激素水平的研究，这些研究都嵌套在合作围产期项目(CPP--见项目ES049016下的说明)中。对孕妇储存的血清进行激素水平分析，并检查与受试者特征的关系。 去年的进展： 描述这项牙科研究的手稿已经准备好，不久将提交给一家期刊。发表了两篇关于怀孕期间荷尔蒙水平的论文，其中一篇提交给了一本期刊。

Diet and other early exposures may affect child development and the risk of several chronic diseases, but additional research is needed. The current research described in this "catch-all" project comprises two subprojects: first, a study of effects due to exposures incurred secondary to dental procedures and treatments during pregnancy, and second, a group of inter-related studies all having to do with hormone levels in women during pregnancy in relation to factors such as race and cryptorchidism in offspring, which are risk factors for testicular germ cell tumors. The study of effects due to exposures incurred secondary to dental procedures and treatments during pregnancy is based on data from the Avon Longitudinal Study of Parents and Children. Data on dental history were available for 8,251 women and the outcomes examined were birth weight, preterm birth, and child's communicative development. Regarding the studies of hormone levels during pregnancy, these were all nested in the Collaborative Perinatal Project (CPP--see description under project ES049016). Stored serum from pregnant women was analyzed for hormone levels and examined in relation to subject characteristics. Last year's progress: A manuscript describing the dental study was prepared and will be submitted to a journal shortly. Two papers on hormone levels in pregnancy were published, and one was submitted to a journal.