Biomarkers of Stress and Health for Los Angeles Children

描述（由申请人提供）：在这个项目中，我们建议将0-17岁儿童的压力和健康生物标志物的收集加入到正在进行的儿童、家庭和社区的纵向研究中。这项研究是洛杉矶家庭和社区调查（L.A.FANS），其设计通过收集社区、家庭、成人和儿童以及住宅选择和社区变化的纵向数据，弥补了许多限制以前社区效应研究的问题。第一波调查（L.A.FANS-1）于2002年1月完成，对洛杉矶县65个社区的3090个家庭的成人和儿童进行了访谈。第二波（L.A.FANS-2）计划于2005-2006年进行，由NICHD和NIA资助，包括收集样本中成人压力和健康的生物标志物，成人和儿童及其照顾者的基于问卷的数据，以及社区社会和身体状况的信息。作为本项目的一部分（L.A.FANS-2/ cb -“儿童生物标志物”），我们建议通过实地调查收集样本中所有0-17岁儿童的压力和健康的类似生物标志物来补充第2波数据收集。数据收集将与主要的l.a.f ans2调查同时进行，这将提高效率并降低成本。这些数据将为研究邻里和家庭环境对儿童健康和福祉的影响提供重要的新资源。

DESCRIPTION (provided by applicant): In this project, we propose to add the collection of biomarkers of stress and health for children aged 0-17 to an ongoing longitudinal study of children, families, and neighborhoods. The study is the Los Angeles Family and Neighborhood Survey (L.A.FANS), whose design remedies many of the problems that have limited previous research on neighborhood effects, by collecting longitudinal data on neighborhoods, families, adults, and children, and on residential choice and neighborhood change. The first wave (L.A.FANS-1), completed in January 2002, interviewed adults and children living in 3,090 households in a diverse stratified probability sample of 65 neighborhoods throughout Los Angeles County. The second wave (L.A.FANS-2), planned for 2005-2006, has been funded by NICHD and NIA and includes the collection of biomarkers of stress and health for adults in the sample, questionnaire-based data on adults and on children and their caregivers, as well as information on neighborhood social and physical conditions. As part of this project (L.A.FANS-2/CB-for "child biomarkers"), we propose to supplement Wave 2 data collection by undertaking fieldwork to collect similar biomarkers of stress and health for all children aged 0-17 in the sample. Data collection will be conducted simultaneously with the main L.A.FANS-2 survey, which will promote efficiency and reduce costs. These data will provide a major new resource for studying the effects of neighborhood and family environments on children's health and well-being. The specific aims of this project are to: (1) Collect physiological markers of stress, disease, and health, including obesity, cortisol (a stress hormone), blood pressure, C-reactive protein (a marker of acute inflammation), Epstein-Barr virus antibodies (a marker of immune function), cholesterol, diabetes, and pulmonary function for all children in L.A.FANS-2; (2) Produce a well-documented data set from these data which, along with the L.A.FANS-1 and L.A.FANS-2 data, will be placed in the public domain for the research community to use in a variety of analyses; and (3) Provide support to the research community interested in using these data. The child biomarker data collected in L.A.FANS-2/CB as part of this project along with other L.A.FANS data will provide an important new resource for a wide range of researchers to investigate the effects of social factors on children's stress, disease, and health.