BEHAVIORAL PHARMACOLOGY OF ALCOHOL

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。该项目的重点是过度饮酒的猴子模型，以直接解决酗酒和酗酒的风险和后果问题。危险因素包括遗传易感性、对环境或药物挑战的压力反应、年龄和性别(包括月经周期阶段)。后果包括器官组织损伤、与组织损伤相关的基因表达的改变、睡眠障碍、昼夜节律的改变、月经周期损伤、脑体积的结构变化以及HPA轴中断。我们还在设计中加入了物种比较，通过测量恒河猴(Macaca Mulatta)和食蟹猴(Macaca Fascularis)的乙醇消耗量。这种方法很像一项人口研究，所有人都接触到相同的饮用乙醇介绍，然后允许至少一年的自由选择饮用乙醇(4%w/v)或水以及每天三餐。课程为期22小时，每周7天。允许获取乙醇并记录饮酒数据的计算机控制设备非常敏感和可靠，但需要一致的环境，例如ONPRC的住房。该项目将利用内分泌学核心、成像核心以及遗传研究和信息学计划。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project focuses on monkey models of excessive alcohol consumption to directly address questions of risk for and consequences of alcohol abuse and alcoholism. The risk factors include genetic predisposition, stress response to environmental or pharmacological challenge, age, and sex (including menstrual cycle phase). Consequences include organ tissue damage, alterations in gene expression related to tissue damage, sleep disturbances, alterations in circadian rhythms, menstrual cycle impairments, structural changes in brain volume, and HPA axis disruptions. We also incorporate a species comparison into the designs by measuring ethanol consumption in both rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques. The approach is much like a population study, where individuals are all exposed to the same introduction to drinking ethanol and then are allowed at least 1 year of a free choice between drinking ethanol (4% w/v) or water along with 3 meals/day. Sessions are 22 hr duration and are given 7 days/week. The computer controlled equipment that allows access to ethanol and records drinking data is very sensitive and reliable, but requires a consistent environment, such as the housing rooms at ONPRC. This project will make use of the endocrinology core, the imaging core, and the genetic research and informatics program.