Ruthenium Catalyzed Bond Activation Reactions

描述（由申请人提供）：本研究的长期目标是研究金属催化的C-H和N-H键活化反应的合成和机理方面。过渡金属催化的C-H和N-H键活化反应是形成各种天然产物和药物制剂的强大合成方法。例如，过渡金属催化的C-H键活化反应可以在环境友好的条件下直接将杂原子官能团引入非反应性烃。过渡金属催化的氢胺化反应是一种以原子经济方式生成胺类化合物的高效方法。此外，不对称版本的氢胺化反应具有很高的立体选择性形成氮化合物的潜力。这些催化反应的最大挑战是设计适用于各种天然产物和药物制剂合成的金属催化剂。本研究的主要目的是研究钌催化的C-H键活化胺和氢胺化反应的合成和机理。本研究旨在通过采用定义明确的钌配合物来获得催化胺的C-H键活化和烯烃的氢胺化反应机制。本研究将为抗癌药物和抗炎药物的合成提供新的催化方法。

DESCRIPTION (provided by applicant): The long term goal of this research is to study synthetic and mechanistic aspects of metal-catalyzed C-H and N-H bond activation reactions. Transition metal-catalyzed C-H and N-H bond activation reactions are powerful synthetic methods for forming a wide variety of natural products and pharmaceutical agents. For example, transition metal-catalyzed C-H bond activation reaction can directly introduce heteroatom functional groups to unreactive hydrocarbons under environmentally benign conditions. Transition metal-catalyzed hydroamination reaction is a highly effective method for forming amine compounds in an atom-economical fashion. Furthermore, asymmetric version of the hydroamination reaction has high potential for stereoselective formation of nitrogen compounds. The paramount challenge for these catalytic reactions is to design metal catalysts which are applicable to the synthesis of a variety of natural products and pharmaceutical agents. The major objective of the proposed research is to study the synthetic and mechanistic aspects of the ruthenium-catalyzed C-H bond activation of amines and hydroamination reactions. This research seeks to gain the reaction mechanisms for catalytic C-H bond activation of amines and hydroamination of alkenes by employing well-defined ruthenium complexes. The proposed research will provide new catalytic methods for the synthesis of anticancer drugs and anti-inflammatory agents.