Real Time Monitoring of Environmental Exposure To Pesticides

描述(由申请人提供) 菲尼克斯生物系统公司打算利用传感器、微流体和微电子学方面的内部专业知识来设计、开发和验证电池供电的新型便携式测量技术，这些技术在第二阶段资助期结束时将产生可现场部署的工具，这些工具将实时提供对优先环境暴露的内部剂量和/或活动的准确内部评估。传感器将有能力测量单一暴露类别内的多种物质，即杀虫剂。第一阶段的原型将检测个人在全血样本中接触OP结合物。由于得到的OP结合物通常与OP结构直接相关，基于抗体的纳米阵列分析将优于当前基于终点的比色方法。

DESCRIPTION (provided by applicant) Phoenix Biosystem intends to leverage the in-house expertise in sensors, microfluidics, and microelectronics to design, develop and validate novel, battery powered portable measurement technologies which, by the end of the Phase II funding period, will result in field-deployable tools that would provide accurate internal assessment of internal dose and/or activity of priority environmental exposures in real time. The sensors would have the ability to measure multiple agents within a single class of exposure i.e. pesticides. The Phase I prototype will detect personal exposure to OP conjugates in whole blood samples. Since the resultant OP conjugate typically correlates directly with the OP structure, an antibody-based nanoarray analysis would be superior to the current, end point-based colorimetric method.