Compact Line-scanning Adaptive Optics Retinal Imager

描述(由申请人提供)：物理科学公司(PSI)在咨询杜克眼科中心的眼科医生后，建议开发一种紧凑型自适应光学行扫描激光眼底镜(AO-LSLO)。该仪器将大大降低自适应光学视网膜相机的尺寸、成本和复杂性，并使高分辨率成像技术在眼科医生、验光师和视觉研究人员中得到更广泛的应用。在拟议的第一阶段计划中，我们将设计和建模光学布局，构建仪器的台式版本，并完成一系列实验，以表征和优化性能并确定概念的可行性。在一个潜在的第二阶段计划中，我们将把设备打包到一个小外壳中，设计成坐在裂隙灯舞台上。在第二阶段计划的后半部分，我们还将在杜克眼科中心对患有视网膜疾病的人类受试者进行临床测试。该仪器将适用于临床研究，用于视网膜疾病的早期发现和进展，直接测量各种视网膜缺陷的结构和功能特征，微视野和心理物理学视力研究，以及确定新的遗传和分子疗法的疗效。通过使高分辨率眼球进入更广泛的范围，拟议的仪器将开始将自适应光学技术引入更多的临床医生和科学家。反过来，这些研究人员将利用这一工具来增加我们对视力及其疾病破坏的理解，并用于开发新的药物和疗法。

DESCRIPTION (provided by applicant): Physical Sciences Inc. (PSI), in consultation with an ophthalmologist from Duke Eye Center, proposes the development of a compact adaptive optics line-scanning laser ophthalmoscope (AO-LSLO). The instrument will greatly reduce the size, cost, and complexity of adaptive optics retinal cameras and lead to more wide-spread use of high-resolution imaging technology by ophthalmologist, optometrist, and vision researchers. In the proposed Phase I program, we will design and model the optical layout, construct a bench-top version of the instrument, and complete a series of experiments to characterize and optimize performance and determine concept feasibility. In a potential Phase II program, we will package the setup into a small housing designed to sit on a slit lamp stage. We will also perform clinical testing on human subjects with retinal diseases at Duke Eye Center in the second half of a Phase II program. The instrument will be amenable to clinical studies for the early detection and progression of retinal disease, direct measurement of the structural and functional characteristics of a wide range of retinal defects, microperimetry and psychophysical vision studies, and for determination of the efficacy of novel genetic and molecular therapies. By making high-resolution ocular access more widespread, the proposed instrument will begin to move adaptive optics technology into a greater number of clinicians and scientists. These researchers will, in turn, use this tool to increase our understanding of vision and its disruption by disease and for the development of new drugs and therapies.