Neurobehavioral Changes in Pediatric Affective Disorder

描述（由申请人提供）：这是一份针对儿科情感障碍（抑郁和焦虑）的项目项目拨款的竞争性续期的修订后重新提交。这些疾病是频繁的、慢性的、复发的，并与显著的发病率、功能损害和死亡率相关。在回应前次检讨时，我们澄清了研究小组提出的问题，就若干研究范畴提供了额外资料和说明，并更清楚地描述了各个项目和核心之间的相互关系。修订后的申请中的四个项目将：(I)研究新的PAD样本和对照受试者在急性治疗前和治疗期间的情绪、认知、行为、睡眠/活动模式、社会活动、媒体使用和家庭环境中日常压力源的模式；(2)研究我们的大型纵向样本的儿童和青少年PAD和对照组，因为他们进入青年成年期的多年历程；(3)利用事件相关功能磁共振成像（event - related fMRI）检测不同奖励偶然性下的奖励预期、奖励体验、损失体验和决策，探讨PAD和对照组儿童参与奖励预期、损失和行为选择的神经行为系统；(4)研究双相情感障碍青少年在家中的情绪、认知和行为，描述他们在接受自然治疗后的日常变化和变化。通过这些项目工作的共同主题包括：涉及积极和消极影响和接近/退缩行为的神经行为系统；血清素能系统，在自然环境中研究复杂行为的重要性；以及了解这些相互关联的疾病的纵向病程的重要性。

DESCRIPTION (provided by applicant): This is a revised re-submission of a competing renewal for a Program Project grant that focuses on pediatric affective disorders (depression and anxiety). These disorders are frequent, chronic, recurrent, and associated with significant morbidity, functional impairment, and mortality. In response to the previous review we have clarified issues raised by the IRG, provided additional information and descriptions regarding several areas of the studies, and have better delineated the inter-relatedness across the projects and cores. The four projects in the revised application will: (I) Study patterns of mood, cognition, behavior, sleep/activity patterns, social activities, media use and daily stressors in home environments in a new sample of PAD and control subjects before and during acute treatment; (2) Study the multi-year course of our large longitudinal sample of children and adolescents with PAD and controls as they enter young adulthood; (3) Use event related fMRI to examine reward-expectancy, experience of reward, experience of loss, and decision-making under varying reward contingencies to investigate the neurobehavioral systems involved in reward-anticipation, loss, and behavioral choice in PAD and control children; (4) Study mood, cognition, and behavior in the home in a sample of bipolar adolescents, characterizing day-to-day variability and changes in response to naturalistic treatment. Common themes through the work of these projects include: the neurobehavioral systems involved in positive and negative affect and approach/withdrawal behaviors; serotonergic systems, the importance of studying complex behavior in a natural setting; and the importance of understanding the longitudinal course of these interrelated disorders.