Correlating Human Electrophysiology and BOLD Activity

描述(由申请人提供)：该方案的目标是将血流动力学BOLD信号与人类内侧颞叶的细胞电生理活动相关联。该项目建议在执行导航任务期间对海马区进行高分辨率结构成像研究。我将使用计算方法来展开大脑各亚区的活动，我将检查海马亚核和海马旁海马区特定层的fMRI BOLD活动。这些患者随后将在这些脑区植入深度电极，作为治疗药物难治性癫痫的切除计划的一部分。使用128个通道的记录系统，允许连续采样宽带电生理数据，将检查脑电和海马区单个神经元的反应。通过检查脑电和单个神经元对行为相关事件的反应，这些信号将与BOLD信号相关联。对对照对象的测试将提供对患者哪些激活可能代表癫痫发作所致损害的洞察，并可以证明我们关于BOLD和电生理学与正常大脑活动之间的相关性的发现是合理的。

DESCRIPTION (provided by applicant): The goal of this proposal is to correlate the hemodynamic BOLD signal with cellular electrophysiological activity in the human medial temporal lobes. This project proposes to perform high-resolution structural imaging studies of the hippocampal area during performance of navigation tasks. Using computational methods that allow unfolding of activity in subregions of the brain, I will examine fMRI BOLD activity in the subnuclei of the hippocampus and specific layers of the parahippoccampal region. These same patients will subsequently be implanted with depth electrodes in these brain regions as part of resection planning for treatment of pharmacologically intractable epilepsy. Using an 128 channel recording system that allows continuous sampling of wide band electrophysiological data, both EEG and single neuron responses in the hippocampal area will be examined. By examining EEG and single neuron responses to behaviorally relevant events, these signals will then be correlated with the BOLD signal. Testing with control subjects will provide insight into which activations in patients may represent impairments due to seizures and can justify comparing our findings on correlations between BOLD and electrophysiology to normal brain activity.