Center For Education and Research in Therapeutics

描述（由申请人提供）：宾夕法尼亚大学治疗学教育和研究中心（PennCERT）建议加强和扩大其基础设施，同时开展研究和教育计划，以更加集中的方式推进治疗学。PennCERT的主题将继续是传染病（抗感染治疗），并增加以下新的副主题（即，我们可以成为整个CERT网络的资源的方法学重点领域）：1）药物流行病学，2）患者安全和3）健康信息技术。我们特别建议： 1.建立和加强我们的研究和教育中心与其协调的基础设施;继续我们在国家CERT计划的积极参与;继续我们的小额赠款计划，资助研究解决相关的治疗问题和试点研究，支持R 01应用的发展;并保持一系列令人印象深刻的数据资源，从PennCERT和其他CERT的调查人员访问。 2.开展研究，以改善有关使用和影响的决策的基本证据基础 抗感染药 3.实施和评价旨在改善门诊和住院病人抗感染药物使用的干预措施， 尤其是住院病人的情况。 4.进行研究方法的教育，医学文献的批判性评价，以及治疗 针对多个受众的决策，包括医学生，毕业医学实习生， 和医疗保健专业人员。 5.传播和翻译我们的工作成果，包括出版物和演示文稿： 科学/专业团体; ii）FDA、AHRQ、其他CERT等;及iii）公众， 伦纳德·戴维斯研究所完善的传播计划。 当前PennCERT应用程序的新功能包括新的调查员（前PennCERT学员谁现在已接受教师职位）;调查人员增加，以加强我们在卫生经济学，生物医学信息学和空间建模的专业知识;增加对儿科的关注，与教师和费城儿童医院计划的一个重大项目;更加关注旨在开发、实施和评估新项目的研究和教育，以将最佳抗菌药物实践的证据转化为日常实践，特别是在医院环境中;四个较大的研究项目，这是因为现有资源增加了;随着早期项目的完成，今后几年选择项目的灵活性增加。

DESCRIPTION (Provided by the Applicant): The University of Pennsylvania Center for Education and Research on Therapeutics (PennCERT) proposes to reinforce and expand its infrastructure, while conducting research and educational programs to advance therapeutics in an even more focused way. The theme of the PennCERT will continue to be infectious diseases (anti-infective therapy) with the following new subthemes (i.e., areas of methodologic focus where we can be a resource for the whole CERT network): 1) pharmacoepidemiology, 2) patient safety, and 3) health information technology. In particular, we propose to: 1. Build on and enhance our research and educational center with its coordinated infrastructure; continue our active participation in the national CERTs program; continue our mini-grant program that funds studies addressing relevant therapeutic questions and pilot studies that support the development of R01 applications; and maintain an impressive series of data resources, accessible to investigators from the PennCERT and other CERTs. 2. Conduct research to improve the underlying evidence base for decisions about the use and effects of anti-infectives. 3. Implement and evaluate interventions aimed at improving the use of anti-infectives in outpatient and especially inpatient settings, locally, regionally, and nationally. 4. Conduct education in research methods, critical appraisal of the medical literature, and therapeutic decisionmaking targeting multiple audiences, including medical students, graduate medical trainees, and health care professionals. 5. Disseminate and translate the results of our work, including publications and presentations: i) for the scientific/professional community; ii) the FDA, AHRQ, other CERTs, etc.; and iii) the public, building on the well-developed dissemination program of the Leonard Davis Institute. New features of the current PennCERT application include new investigators (former PennCERT trainees who have now accepted positions as faculty); investigators added to strengthen our expertise in health economics, biomedical informatics, and spatial modeling; an increased focus on pediatrics, with faculty and a major project planned at Children's Hospital of Philadelphia; an increased focus on research and education intended to develop, implement, and evaluate novel programs for translating evidence on optimal antimicrobial drug practices into everyday practice, particularly in hospital settings; four larger research projects, possible because of the increased resources now available; and an increased flexibility in choice of projects in future years, as earlier projects are completed.