Behavior & Clinical Trials Participation in HIV+ Latinos

描述(申请人提供)：通过这个研究职业发展奖，我将完成初步步骤，确立自己作为艾滋病毒/艾滋病行为研究的独立研究员，以减少感染艾滋病毒的拉丁裔社区的健康差距。使用授课和指导学习，我将改进我现有的行为、定性和定量研究技能，以解决拉美裔社区艾滋病毒/艾滋病临床试验参与率较低的问题。少数群体在研究试验中的比例代表性对于提高研究能力，将结果推广到感染艾滋病毒的不同人群是必要的。我的具体研究目的是：1)描述和了解与HIV+墨西哥裔拉丁裔进入临床试验相关的态度、信仰、文化和社会规范、提供者和系统影响，以及2)开发和试行干预措施，以提高对HIV+墨西哥裔拉丁裔及其社区参与艾滋病毒临床试验的理解和接受。该研究计划的理论框架是卫生服务使用行为模型(Andersen，Aday等人)。研究计划将分三个阶段进行，每个阶段都与职业发展目标和活动相联系。在第一阶段，我将使用定性方法对HIV+墨西哥裔拉美裔进行形成性研究，包括设计和实施深入访谈方案和焦点小组问题，以探索在试图改善拉美裔人群临床试验参与度时需要考虑的因素。在第二阶段，我将进行定性分析，开发参与研究的社会认知模型，开发研究假设，并开发和试点测试一项调查，以测试HIV+墨西哥裔拉丁裔的社会认知模型。在第三阶段，我将验证调查，分析和报告结果，设计并试行行为干预措施，以增加艾滋病毒+墨西哥裔拉丁裔的临床试验参与率，最后，使用干预试点数据准备向NIH提交的R01提案，以促进艾滋病毒+拉丁裔参与临床试验。

DESCRIPTION (provided by applicant): Through this research career development award, I will complete the initial steps to establish myself as an independent researcher in HIV/AIDS behavioral research to reduce health disparities in Latino communities infected with HIV. Using didactic and mentored learning, I will improve upon my existing behavioral, qualitative, and quantitative research skills to address the issue of low participation in HIV/AIDS clinical trials in Latino communities. Proportionate representation of minority populations in research trials is necessary to improve research capacity to generalize results to diverse populations infected with HIV. My specific research aims are to: 1) Describe and understand the attitudes, beliefs, cultural and social norms, provider and system influences relating to entry into clinical trials in HIV+ Mexican-origin Latinos, and 2) Develop and pilot test an intervention for improving understanding and acceptance of HIV clinical trials participation by HIV+ Mexican-origin Latinos and their communities. The theoretical framework of the research plan is the Behavioral Model of Health Services Use (Andersen, Aday, et al.). The research plan will be carried out in three phases, each phase linked to a career development objective and activity. In Phase 1 I will conduct formative research using qualitative methods with HIV+ Mexican-origin Latinos, including design and implementation of an in-depth interview protocol and focus group questions to explore factors to consider in attempting to improve clinical trials participation in Latino populations. In Phase 2 I will carry out qualitative analysis, develop a social cognitive model of participation in research, develop research hypotheses, and develop and pilot test a survey to test the social cognitive model in HIV+ Mexican-origin Latinos. In Phase 3 I will validate the survey, analyze and report outcomes, design and pilot-test a behavioral intervention to increase clinical trials participation in HIV+ Mexican-origin Latinos, and finally, use intervention pilot data to prepare an R01 proposal to the NIH to promote participation of HIV+ Latinos in clinical trials.