Monoclonal Antibody Imaging Of Tumors And Positron Emmis

这些抗体研究旨在发展检测和治疗恶性肿瘤的改进方法。我们的小组进行临床前评估放射标记抗体，似乎是有希望的初步筛选后。临床试验评价其药代动力学和剂量学是由我组完成的。一项成人t细胞白血病（ATL）的放射免疫治疗试验已经完成。与Waldmann博士（PI）合作的一项放射免疫治疗试验正在进行中，我们在非ATL淋巴瘤患者中使用人源化抗tac单克隆抗体，4名霍奇金淋巴瘤患者中有3名表现出肿瘤反应。他的化学工作主要集中在球形聚合物（PAMAM树突状聚合物）的化学修饰上，作为放射性核素和生物分子的载体，包括血管生成的标志物。在PET中使用[F-18] FDG和[O-15]水中使用[F-18] FDG进行肿瘤检测、随访和血流量测量的各种方案正在NCI中进行。我们继续使用FDG作为各种恶性肿瘤反应和疾病状态的替代标记物。我们继续以先前的研究为基础，利用氟脱氧葡萄糖PET试图定位活化淋巴细胞的位置。我们继续评估FDG-PET在自身免疫性淋巴细胞增生性综合征与恶性淋巴瘤患者之间的区分能力。我们正在与成像科学项目和NIAID合作，评估新的示踪剂，以评估体外HIV感染的发病机制。

These antibody studies are designed to develop improved methods for detecting and treating malignancies. Our group performs preclinical evaluation of radiolabeled antibodies that appear to be promising after initial screening. The clinical trials evaluating their pharmacokinetics and dosimetry are performed by our group. One raidoimmunotherapy trial of Adult T-cell leukemia (ATL) has been completed. One collaborative radioimmunotherapy trial with Dr. Waldmann (PI), in which we used humanized anti-tac monoclonal antibody,in patients with non ATL lymphomas is ongoing and 3 of 4 patients with Hodgkin's have exhibited tumor response. Dr. Paik has focused his chemistry work on the chemical modification of spherical polymers (PAMAM dendrimers) as carriers of radionuclides and biological molecules including markers of angiogenesis. Various protocols using [F-18] FDG in PET and [O-15] water for tumor detection, followup, and blood flow measurements are ongoing with NCI. We continue work using FDG as a surrogate marker of resposne and disease status in a variety of malignacy. We continue to build on prior studies and are utilizing fluorodeoxyglucose PET in attemps to localize sites of activated lymphomcytes. We continue to evaluate the ability of FDG-PET to differentiate between patients with benign versus lymphomatous adenopathy in the setting of autoimmune lymphoprolifertive syndrome versus. We are collaborating within the Imaging science program and NIAID in evalauting new tracer to evaluate the pathogenesis of HIV infection in vitro.