CORE 3: INFRASTRUCTURE

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 生物医学工程系和HiT中心成员。HiT中心旨在支持和促进大型跨学科和技术开发项目，例如为TCNP提出的项目。HiT中心由几个具有高度先进的核心设施的教师研究小组组成;因此，已经存在相当大的基础设施来支持拟议的项目。我们建议在这个基础设施中增加一个计算生物学核心，以满足TCNP研究人员的特定计算需求。 在计算生物学支持核心中，Bader博士和他在生物医学工程领域的同事Andre Levchenko博士将为TCNP的所有成员提供计算支持服务。这两个人都是蛋白质相互作用网络和途径的计算生物学专家。 Levchenko博士在动态网络和代谢和信号通路的定量变化建模方面具有特殊的专业知识

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Department of Biomedical Engineering and member of the HiT Center. The HiT Center was expressly designed to support and facilitate large, interdisciplinary and technology development projects such as that proposed for this TCNP. The HiT Center consists of several faculty research groups side by side with highly advanced core facilities; thus considerable infrastructure to support the proposed project already exists. We propose to add to this infrastructure a computational biology core designed to meet the specific computational needs of the investigators in the TCNP. In the computational biology support core, Dr. Bader, together with his colleague in Biomedical Engineering, Dr. Andre Levchenko, will provide computational support services for all members of this TCNP. Both of these individuals are experts in the computational biology of protein interaction networks and pathways. Dr. Levchenko has special expertise in dynamic networks and modeling quantitative changes in metabolic and signaling pathways