POLIOVIRUS-SIV VACCINES IN PREGNANT AND INFANT MACAQUES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。目的：消除儿童HIV感染的最重要手段是预防妇女在怀孕前或怀孕期间感染HIV。然而，关于疫苗预防孕妇经阴道传播艾滋病毒或在妊娠、分娩或母乳中母婴传播艾滋病毒的效力的资料很少。SIV/食蟹猴模型最近已被用于证明由表达多种SIV抗原的活的重组Sabin脊髓灰质炎组成的疫苗具有免疫原性，并且可以引发针对致病性SIV阴道攻击的保护。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: The most important means of eliminating pediatric HIV infection is to prevent women from becoming HIV-infected before or during pregnancy. However, there is little information regarding the efficacy of vaccines to prevent vaginal HIV transmission in pregnant women or HIV transmission from mother to infant during gestation, delivery or by breastmilk. The SIV/cynomolgus macaque model has been recently used to demonstrate that a vaccine consisting of live, recombinant Sabin polio expressing multiple SIV antigens is immunogenic and can elicit protection against vaginal challenge with pathogenic SIV.