RHESUS MACAQUE PSYCHOTROPIC DOSAGE ADMINISTRATION

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。目的：对精神分裂症患者大脑的尸检研究表明，抑制性GABA（γ-氨基丁酸）和兴奋性谷氨酸神经递质系统的基因表达发生了变化。这些发现的重要性是有限的，因为治疗和药物的可能混淆。因此，重要的是要确定这些药物对基因表达的影响，在灵长类动物的良好控制实验。目前已完成的实验的目的是确定用于治疗情感性精神分裂症和情感性精神障碍的常用精神药物对大脑中mRNA和蛋白质表达的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: Postmortem studies of human brains from patients with schizophrenia have implicated changes in gene expression in the inhibitory GABA(gamma amino butyric acid) and excitatory glutamate neurotransmitter systems. The importance of these findings is limited because of the possible confounds of treatment and medications. Therefore, it is important to determine the effects of these medications on gene expression in well-controlled experiments in primates. The aim of the experiments, now completed, was to determine the effects of commonly used psychotropic medications for the treatment of affective disorder schizophrenia and schizoaffective disorder on mRNA and protein expression in the brain.