APPLICATION OF TRANSGENIC TECHNOLOGIES TO BABOONS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。在狒狒模型中研究的许多人类疾病至少部分基于遗传病因学。转基因已经成为一个非常有价值的工具，在整个动物，在小鼠体内的基因功能的研究，但它往往是不可能准确地模拟在这个或其他非灵长类动物物种的相关复杂的灵长类动物的生理学。因此，转基因技术在狒狒实验研究中的应用将为生物医学研究创造一个强大的新的遗传、发育和生理模型系统。该项目的长期目标是开发生产转基因狒狒的技术。近期目标是证明转基因狒狒胚胎生产的可行性和优化效率，并提高产生转基因后代的概率。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Many of the human disorders studied in baboon models are based, at least in part, on a genetic etiology. Transgenesis has been an extremely valuable tool for whole animal, in vivo studies of gene function in the mouse, but it is often not possible to accurately mimic the relevant complex primate physiology in this or other non-primate species. Thus, the availability of transgenic technology for experimental research with baboons would create a powerful new genetic, developmental and physiological model system for biomedical research. The long-term goal of this project is to develop technology for producing transgenic baboons. The immediate goals are to demonstrate the feasibility and to optimize the efficiency of producing transgenic baboon embryos, and to improve the probability of yielding transgenic offspring.