INTRINSIC SIGNAL IMAGING IN THE BRAIN

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。在这项研究中，我们建议使用光谱和偏振技术，推动光学固有信号成像（ISI）的限制，对测量快速响应的照明皮层刺激输入。在本研究中，快速信号定义为发生时间短于血流动力学反应的信号，血流动力学反应发生在秒级。因此，我们建议对皮质中的光反射率变化进行成像，这些变化是由于激活的神经元中的电信号（约10毫秒）和脱氧血红蛋白的瞬时增加（称为初始下降）（约100毫秒）。这种快速信号对于理解至关重要，因为它们是大脑对刺激反应中最不为人所知的部分，并且是神经活动的直接测量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this study, we propose to use spectroscopic and polarimetric techniques to push the limits of optical intrinsic signal imaging (ISI) towards measuring the fast response of an illuminated cortex to a stimulus input. For this study, fast signals are defined as those that take place on timescales shorter than the hemodynamic response, which occurs on the order of seconds. Thus we propose to image light reflectance changes in the cortex that are due to electrical signals in the activated neurons (~10s of milliseconds) and to the transient increase in deoxygenated hemoglobin known as the initial dip (~100s of milliseconds). Such fast signals are crucial to understand because they are the least understood part of the brain response to a stimulus and are a direct measure of neural activity.