LOOK AHEAD: ACTION FOR HEALTH IN DIABETES

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。Look AHEAD的主要目的是在超重的2型糖尿病志愿者中检查强化生活方式干预计划的长期效果，该计划旨在通过减少热量摄入和增加体力活动来实现和维持体重减轻。将该计划与接受糖尿病支持和教育的对照组进行比较。将在两个治疗组之间进行比较的主要结局是严重心血管事件的发生率。其他结果包括心血管疾病风险因素、糖尿病相关代谢因素和并发症以及强化干预的成本效益。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of Look AHEAD is to examine, in overweight volunteers with type 2 diabetes, the long-term effects of an intensive lifestyle intervention program designed to achieve and maintain weight loss by decreased caloric intake and increased physical activity. This program is compared to a control group receiving diabetes support and education. The primary outcome, which will be compared between the two treatment groups, is the incidence of serious cardiovascular events. Other outcomes include cardiovascular disease risk factors, diabetes-related metabolic factors and complications, and cost-effectiveness of the intensive intervention.