SUPPLEMENTAL INTRAVENOUS IRON THERAPY FOR RLS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。不宁腿综合征（RLS）是一种常见的睡眠障碍，据报道影响人口的2%至5%。虽然RLS的病理生理学尚不清楚，但有大量的临床前和临床研究表明脑缺铁。PI正在研究IV铁剂治疗RLS的效果。拟议的研究将评估补充IV铁治疗对先前对IV铁有反应的患者的疗效。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Restless legs syndrome (RLS) is a common sleep disorder that is reported to effect between 2 and 5% of the population. Although the pathophysiology of RLS is unknown, there is a significant body of preclinical and clinical research that implicates brain iron deficiency. The PI has an ongoing protocol to investigate the effect of IV iron for the treatment of RLS. The proposed research will assess the efficacy of supplemental IV iron therapy in those that responded to IV iron previously.