TREATMENT PREDICTION IN ADOLESCENT AND ADULT DEPRESSION

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。尽管有越来越多的证据表明青春期和成年期抑郁症持续存在，在临床表现和自然病史上有相似之处，但成熟期的差异也得到了强调。具体地说，一些研究报告称，与成年人相比，抑郁症青少年的脑电(EEG)清除变化、下丘脑-垂体-肾上腺(HPA)活动和抗抑郁(AD)反应存在差异。这项建议旨在了解这些发育差异背后的机制(S)，并制定一种策略，用于识别那些可能从AD治疗中受益的患者，包括青少年和成年人，特别是安非他酮治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although there is growing evidence for continuities in adolescent and adult depression, with similarities in clinical presentation and natural history, maturational differences also have been highlighted. Specifically, several studies reported variation in electroencephalographic (EEG) cleep changes, hypothalamic-pituitary-adrenal (HPA) activity and antidepressant (AD) response in depressed adolescents compared with the findings in adults. This proposal aims to understand the mechanism(s) underlying these developmental differences and to develop a strategy for use in identifying those patient, both youngsters and adults, who might benefit from AD treatment in general, and from bupropion treatment in particular.