HEALTH OUTREACH PROGRAM FOR THE ELDERLY (HOPE)

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。波士顿大学阿尔茨海默病中心（BU ADC）是美国国立卫生研究院（NIH）资助的32个中心之一，负责提供与阿尔茨海默病（AD）相关的研究，教育和临床护理。BU ADC由5个核心组成：行政，临床，教育和信息传递，神经病理学和小鼠育种。研究，教育和临床护理的功能是在五个核心之一的主持下完成的。核心支持几个重点或兴趣领域：AD的遗传和环境风险，晚期demetia，家庭和专业护理以及涉及非裔美国人的研究。NIH最近退还了BU ADC从2001年7月开始的五年期。 BU ADC临床核心的主要目的是通过提供来自流动和晚期人群的特征良好的患者、对照和护理人员人群的信息和材料，促进BU和全国的AD研究。BU ADC已经建立了一个由痴呆症患者和认知正常的参与者组成的注册表。这被称为临床核心的患者/对照登记研究。患者/对照登记研究中登记的患者和对照组每年进行一次标准化神经系统检查和神经心理学成套测试。采集并储存血液用于分子遗传学研究。还获得详细的医疗，社会和家庭史。将该信息输入数据库，用于纵向比较和与AD进展及其对护理人员的影响的相关性。受试者、数据和血液/DNA可供合格的研究人员使用，以刺激对AD和正常衰老的新研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Boston University Alzheimer's Disease Center (BU ADC) is one of 32 National Institutes of Health (NIH) funded centers mandated to provide research, education and clinical care related to Alzheimer's disease (AD). The BU ADC is comprised of 5 Cores: Administrative, Clinical, Education and Information Transfer, Neuropathology and Murine Breeding. The functions of research, education and clinical care are accomplished under the auspices of one of the five Cores. The Cores support several areas of emphasis or interest: genetic and environmental risks for AD, late stage demetia, family and professional care giving and studies involving African Americans. NIH has recently refunded the BU ADC for a five-year period beginning in July of 2001. The primary purpose of the Clinical Core of the BU ADC is to promote research on AD at BU and throughout the country by providing information and materials from well characterized patient, control and caregiver populations drawn from ambulatory and late-stage populations. The BU ADC has established a Registry comprised of participants with dementia and participants with normal cognition. This is known as the Patient/Control Registry of the Clinical Core. Patients and controls enrolled in the Patient/Control Registry are assessed annually with a standardized neurological examination and neurophsychological test battery. Blood is obtained and stored for molecular genetic studies. A detailed medical, social and family history is also obtained. This information is entered into a database for longitudinal comparisons and correlation with the progression of AD and its impact on caregivers. Subjects, data and blood/DNA are made available to qualified researchers to stimulate new research in AD and normal aging.