REGULATION OF NUTRIENT-STIMULATED INSULIN SECRETION BY GLP-1

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究旨在检测肠道激素GLP-1对健康人及糖尿病患者胰岛素分泌的控制作用。为了进行这项研究，研究人员将在两次餐后测量志愿者的胰岛素水平。在一项研究中，GLP-1的效果将通过给予一种名为exendin-(9-39)的GLP-1阻滞剂来确定。通过比较阻断GLP-1和不阻断GLP-1的胰岛素分泌情况，可以从两项研究的差异中估计GLP-1的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is designed to test the effect of the intestinal hormone GLP-1 to control insulin secretion in healthy persons and those with diabetes. To do this research volunteers will have insulin levels measured after meals on two occasions. The effect of GLP-1 will be determined by giving a blocker of GLP-,1 called exendin-(9-39, in one of the studies. By comparing insulin secretion with and without GLP-1 blockade, the effect of GLP-1 can be estimated from the difference in the two studies.