PCOS RISK OF PREMATURE PUBERTY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。该项目的总体目标是确定哪些青春期过早的女孩有发展为PCOS的风险。将检验三个假设。假设1：促性腺激素释放激素激动剂（GnRHag）后17-羟孕酮（17 HPROG）对人绒毛膜促性腺激素（hCG）卵巢功能试验的反应高于单独使用。假设二：17 HPROG对hCG反应的大小与超声显示的卵泡数量、17-羟孕酮（17 HPREG）对ACTH的反应和胰岛素抵抗指数相关。假设三：睾酮水平的最高四分位数将在17 <$-羟基类固醇脱氢酶5型基因的候选激活变体（“G变体”）纯合的患者中发现。为了检验这些假设，6-9岁的青春期过早女孩将接受葡萄糖耐量、促肾上腺皮质激素、促性腺激素释放激素激动剂（亮丙瑞林）和人绒毛膜促性腺激素检测以及盆腔超声检查。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this project is to determine which girls with premature pubarche are at risk of developing PCOS. Three hypotheses will be tested. Hypothesis 1: The 17-hydroxyprogesterone (17HPROG) response to a human chorionic gonadotropin (hCG) test of ovarian function will be higher after gonadotropin releasing hormone agonist (GnRHag) than alone. Hypothesis 2: The magnitude of the 17HPROG response to hCG will correlate with the number of ovarian follicles on ultrasound, the 17-hydroxypregnenolone (17HPREG) response to ACTH, and indexes of insulin resistance. Hypothesis 3: The highest quartile of testosterone levels will be found in patients homozygous for a candidate activating variant ("G-variant") of the 17¿-hydroxysteroid dehydrogenase type 5 gene. To test these hypotheses, 6-9 year old girls with premature pubarche will undergo glucose tolerance, cosyntropin, gonadotropin releasing hormone agonist (leuprolide), and human chorionic gonadotropin testing and a pelvic ultrasound examination.