MECHANISMS DEFENDING FAT MASS IN HUMANS AFTER LIPECTOMY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。没有人能肯定抽脂术去除的脂肪是永久性的。本研究的目的就是要回答这个问题。我们将探讨遗传学和代谢对抽脂术脂肪去除反应的可能性。脂肪活检将在抽脂前和抽脂后进行两次以上，以确定哪些基因表达以及它们的表达如何预测和/或与抽脂部位和身体其他部位的体脂变化相关。将有两组受试者参加。第一组将在抽脂前和抽脂后3年内进行检查，而第二组将在3年内进行类似的测量，但没有抽脂。然而，在研究期间未接受抽脂术的受试者组将有机会在3年后以较低的费用进行抽脂术。这项研究将有助于回答一个关于普通整容手术的重要问题，这可能会为人体脂肪的调节提供更多的见解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. No one is sure that the fat removed by liposuction is permanent. The purpose of this study is to answer this question. We will explore the possibility that genetics and metabolism contribute to the response of fat removal by liposuction. Fat biopsies will be carried out before and twice more after liposuction to determine what genes are expressed and how their expression predicts and/or relates to changes in body fat at the liposuction site and elsewhere in the body. Two groups of subjects will participate. The first group will be examined before and up to 3 years after liposuction, whereas the second group will have similar measurements over 3 years but no liposuction. However, the group of subjects who do not receive liposuction during the study period will have an opportunity to have liposuction performed after 3 years at a reduced cost. This study will help to answer an important question about a common cosmetic surgery that may provide additional insights into how body fat is regulated in humans.