DOPAMINE-RLS CONNECTION

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。不宁腿综合征（RLS）是一种感觉运动障碍，多巴胺能系统和脑铁似乎在其中发挥作用。超过98%的RLS受试者对左旋多巴的显著症状反应以及多巴胺（DA）拮抗剂诱导的RLS样症状，为多巴胺能系统在RLS症状本身的产生中所起的作用提供了令人信服的证据。尸检、脑脊液、MRI和静脉铁治疗数据表明脑铁缺乏在RLS中的作用。本研究旨在探讨垂体后叶（催乳素搏动）、黑质纹状体（中脑和纹状体的PET成像）和中边缘（腹侧纹状体/n的PET成像）的异常。白天的多巴胺能系统。DA-2受体（D2R）结合电位和Bmax， DAT将在上午8:30 - 12:00使用最先进的PET成像技术进行测量。在DA系统中发现的任何变化都将与MRI测量的区域脑铁浓度和临床严重程度相关联。特发性RLS患者和年龄匹配的对照组将在本阶段进行研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Restless Legs Syndrome (RLS) is a sensory-motor disorder in which the dopaminergic system and brain iron appear to play a role. The dramatic symptomatic response to L-DOPA in over 98% of RLS subjects and the induction of RLS-like symptoms with dopamine (DA) antagonists provide convincing evidence for the role of the dopaminergic system in the production of RLS symptoms per se. The autopsy, CSF, MRI, and IV iron treatment data indicate a role of BRAIN iron deficiency in RLS. This study is designed to explore for abnormalities in the tuberoinfundibular (prolactin pulsatility), nigrostriatal (PET imaging of midbrain and striatum), and mesolimbic (PET imaging of ventral striatum/n. accumbens) Dopaminergic systems during the day. The DA-2 receptor (D2R) binding potential and Bmax, DAT will be measured with state-of-the-art PET imaging techniques from 8:30 - 12:00 AM. Any changes that are found in the DA system will be correlated with MRI measures of regional brain iron concentrations and measures of clinical severity. Idiopathic RLS patients and aged-matched controls will be studied in this Phase.