EFFECT OF ACUTE NICOTINE ADMINISTRATION ON MOTOR PERFORMANCE IN ADHD

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。患有注意力缺陷/多动障碍(ADHD)的青少年成为吸烟者的风险似乎比非ADHD青少年高得多。其中一个原因可能是烟草中的精神活性成分尼古丁可能对ADHD的一些症状有有益的影响，使吸烟的经历对ADHD患者来说更加强烈。我们有初步证据表明，尼古丁对ADHD的一些核心认知缺陷有明显的积极影响。我们认为，尼古丁对ADHD患者的运动功能也有积极影响，尼古丁对认知和运动症状的积极影响可能会大大增加这些青少年和成年人长期吸烟/滥用烟草的风险。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Adolescents who suffer from Attention-Deficit/Hyperactivity Disorder (ADHD) appear to be at substantially higher risk of becoming cigarette smokers than non-ADHD adolescents. One reason for this may be that nicotine, the psychoactive ingredient in tobacco, may have beneficial effects on some of the symptoms of ADHD making the experience of smoking more reinforcing for individuals with ADHD. We have preliminary evidence that nicotine has acute positive effects on some of the core cognitive deficits in ADHD. We believe that nicotine may also have positive effects on motor functioning in ADHD, and that the positive effects on nicotine on both cognitive and motor symptoms may contribute substantially to the higher risk of chronic tobacco use/abuse in these adolescents and adults.