THE SIGNIFICANCE OF AN ANTENATAL NUCHAL CORD

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究的目的是确定无症状的产前脐带绕颈是否有临床意义，如果有，是否是制定治疗计划的任何潜在价值的辅助发现。分娩过程中脐带绕颈与胎儿窘迫和某些情况下的不良结局有关。妊娠和分娩期间脐带绕颈的真实发生率，以及这些时期脐带绕颈婴儿的结局尚不清楚。每名孕妇将在24-26周、30-32周、36-38周和分娩时进行研究。具体的产前测量包括脐带超声波检测、无压力测试、生物物理学特征以及脐和脑循环的向量测量。后续研究将在婴儿5天和1岁时进行，包括形态测量和神经发育参数。脐带绕颈的存在将与当时的生物物理测试和婴儿的结局（生长、头部超声和Bayley评分）相关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to determine if the presence of an asymptomatic antenatal nuchal cord has clinical significance and, if so, are ancillary findings of any potential value in formulating a management plan. Nuchal cords during labor are associated with fetal distress and poor outcomes in some cases. The true incidence of nuchal cords during pregnancy and labor, and the outcome of infants with nuchal cords at these times is unknown. Each pregnant woman will be studied at 24-26 weeks, 30-32 weeks, 36-38 weeks, and labor. Specific antenatal measurements include ultrasonic detection of a nuchal cord, non-stress test, biophysical profile and vecilometry of the umbilical and brain circulation. Follow-up studies will be done in the infants at five days and one year of life and include morphometric and neurodevelopmental parameters. The presence of nuchal cord will be correlated with biophysical testing at that time and outcomes in the infant (growth, head ultrasound, and Bayley scores).