RESTING ENERGY EXPENDITURE AND AMINO ACID SUPPLEMENTAITON IN YOUNG HEALTHY AD

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。背景：人类对EAA的时间进程知之甚少。因此，该项目的目的是支持我们对肌肉蛋白质代谢和营养的持续兴趣，使用EAA的混合物。具体目标和程序：我们假设，与水对照组相比，年轻健康成年人的能量消耗会更高。我们将使用一台计算机来测量年轻健康成年人的静息能量消耗，该计算机测量静息时氧气消耗和二氧化碳产生的速率。到达后，受试者将被同意，并将获得生命体征、体重和身高。受试者将摄入15克蛋白质，并在气泡下进行两个独立的两个小时的呼吸块，中间隔着方便的休息时间，受试者要么去洗手间，要么伸展身体以减少姿势痉挛或僵硬。在短暂的休息之后，将测量另外两个小时的气体测量数据。在这项测试之后，将使用低位X射线机(DEXA)测量身体成分测试。意义：这项研究的吸引力在于，在卡路里数量有限的情况下，可能会增加身体虚弱或运动能力有限的人的能量消耗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: Little is known about the time course of the EAA in humans. Therefore the purpose of the project is to support our ongoing interests in muscle protein metabolism and nutrition using a blend of EAA. Specific Aims and Procedures: We hypothesize that energy expenditure will be higher in younger healthy adults compared to the water control. We will measure resting energy expenditure in young healthy adults using a computer that measures the rate of oxygen consumed and carbon dioxide produced at rest. Upon arriving the subject will be consented and vital signs and weight and height will be obtained. The subject will take 15 grams of protein and have two separate 2-hour blocks of breathing under a bubble separated by a convenience break in which the subject will either go to the bathroom or stretch to reduce positional cramps or stiffness. Following a brief break, another two hour block of gas measurements will be measured. Following this test a body composition test will be measured using a low level x-ray machine (DEXA). Significance: The appeal of this study is that with a limited number of calories it might be possible to increase energy expenditures in persons who are infirmed and or those who have limited exercise capacity.