Functional Genome/Proteomic Analysis of Pathogen-Host Interactions

超出空间 但前提是。 这只科布雷利用了俄克拉何马州为数不多的生物医学研究领域之一 这是近年来对细菌致病机理的基因组尺度分析的前沿。我们提议 建立以细菌-宿主功能基因组/蛋白质组分析为主题的COBRE 互动。四名初级调查人员在三个主要的州立大学校园得到了资助。我们 取得了惊人的成功率。所有这些人后来都接受了NIH的同行审查 提供资金并从赠款中轮换。他们的成功使我们得以资助另外四名调查人员 他们正处于完成其研究项目的不同阶段。最初的COBRE被构造为 典型的计划项目拨款，但专注于俄克拉荷马州的年轻、发展中的科学家。从… 第二至五年，我们已发展津贴的结构和运作，以配合 原始RFA的后续迭代(RR-00-003)。这包括最多三年的资金， 毕业程序，导师角色更有条理，包括4个初级项目和2个一年试点 项目。这个应用程序继续了主旋律，更直接地关注蛋白质组学。支持 为了这个目标，我们正在建立一个蛋白质组学核心实验室，我们正在招募一个蛋白质组学磁铁 调查员。对该职位的机构支持包括一个专门的终身教职职位和一个 机构资助的创业包增强。我们还预留了2-5年的资金，以帮助所有 俄克拉荷马州与此COBRE有关的机构和俄克拉荷马州INBRE赠款在招聘工作中 吸引与研究主题一致的调查人员。此外，与公共关系办公室的个人信息系统有关 另外两笔COBRE赠款在校园内，我们正在建立联合研究务虚会和会议，以增强 在我们资助的研究人员中提供跨学科的研究机会。眼镜蛇是由一个 NIH资助的知名调查员，他与INBRE-PI一起领导了一项全州范围的倡议，该倡议包括 俄克拉荷马州的三个主要的公共支持的研究机构和一个由12人组成的网络 包括俄克拉何马州唯一的历史上唯一的黑人大学在内的机构，这是一所拥有 美国原住民人数在全国所有大学中最多，俄克拉荷马州唯一的部落学院和几所 其他有大量学生来自代表人数不足的群体的机构。

EXCEED THE SPACE PROVIDED. This COBRE has exploited one of the few areas of biomedical research where Oklahoma has been in the forefront in recent years,which is the genome-scale analysis of bacterial pathogenesis. We proposed to establish a COBRE,with the thematic focus of Functional Genomic/Proteomic Analysis of Bacterial-Host Interactions. Four junior investigators were funded on the three main state university campuses. We achieved a phenomenal success rate. All these individuals have subsequently received peer-reviewed NIH funding and rotated off the grant. Their successes have allowed us to fund an additional four investigators who in are various stages of completion of their research projects. The original COBREwas structured as a typical Program Project Grant, but focused on young, developing scientists in the state of Oklahoma. From years 2 -5 we have evolved the structure and operation of the grant to keep pace with changes in subsequent iterations of the original RFA (RR-00-003). This included a maximum of three years of funding, graduation procedures, more structured roles for mentors, inclusion 4 junior projects and 2 one-year pilot projects. This application continues the main theme with a more directed focus into proteomics. To support this goal, we are establishing a proteomics core laboratory and we are recruiting a proteomics magnet investigator. Institutional support for this position includes a dedicated tenure-earning position and a institutionally funded start-up package enhancement. We also have reserved funds in years 2-5 to assist all Oklahoma institutions associated with this COBREand the Oklahoma INBRE grant in recruitment efforts to attract investigators who are consistent with the research theme. Further, in association with the Pis of the two other COBREgrants on campus, we are instituting joint research retreats and meetings to enhance interdisciplinary research opportunities among our funded investigators. The COBRE is headed by an established NIH-funded investigator who leads a state-wide initiative along with the INBRE-PI that includes the three major publicly-supported research institutions in the state of Oklahoma and a network of 12 institutions including Oklahoma's only historically black university, an undergraduate institution with the highest number of native Americans of any college in the nation, Oklahoma's only tribal college and several other institutions with large numbers of students from under-represented groups.