COBRE: RIH:CORE A: ADMINISTRATION & CAREER DVMT

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。CCRD的使命是基于导致胃肠道癌症的细胞和分子途径的原始，协作，多学科实验室研究，创造，解释和应用新知识。这一广泛的研究领域由研究人员代表，他们从事与四个主要主题相关的研究：主题A -胎儿蛋白和表型在癌症中的意义；主题B：胃肠道肿瘤的发病机制；主题C：肿瘤发生相关的信号转导机制；主题D: RNA和DNA病毒在癌症中的作用。在过去的四年中，CCRD支持的研究范围已经扩大到胃肠道癌症以外，现在包括检查与乳腺癌、前列腺癌、肾癌和肺癌相关的分子事件的项目。为了反映这一范围的变化，并强调正在进行的研究的转化潜力，我们的总体主题现在将成为“癌症干预的分子目标”，这一主题产生了更广阔的基础研究视野，我们认为这将鼓励研究人员找到创造性的方法，将肿瘤分子基础的新见解转化为改进的诊断和治疗方法。正在考虑的可能的子主题包括：预测治疗反应、预后、分期的生物标志物；利用siRNA、特异性抑制剂等进行分子干预的靶点；靶向信号通路，增加对常规治疗的敏感性；以环境、生理或传染因子为目标的分子途径。我们将在2006年5月24日的研讨会上向外部咨询委员会介绍这些变化。COBRE CCRD网站可在www.RIH-COBRE-CARES.org找到。上面列出了NCRR对这个中心的资助。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The mission of the CCRD is to create, interpret, and apply new knowledge based on original, collaborative, multidisciplinary laboratory studies of the cellular and molecular pathways leading to gastrointestinal cancer. This broad area of research is represented by investigators pursuing research relevant to four major themes - Theme A - The significance of fetal proteins and phenotypes in Cancer; Theme B - Pathogenesis Of GI Tumors; Theme C - Signal Transduction Mechanisms Relevant to Carcinogenesis; Theme D - Role of RNA and DNA Viruses in Cancer. Over the last four years, the scope of research supported by the CCRD has broadened beyond gastrointestinal cancer and now includes projects examining molecular events relevant to breast, prostate, kidney and lung cancer. To reflect this change in scope and to emphasize the translational potential of ongoing research, our overall theme will now become ¿Molecular Targets for Cancer Intervention¿, a theme that engenders a broader vision of basic research that we feel will encourage investigators to find creative ways to translate new insights into the molecular basis of neoplasia into improved methods for diagnosis and treatment. Possible sub themes being considered include: Biomarkers for predicting response to therapy, prognosis, staging; Targets for molecular intervention using siRNA, specific inhibitors etc; Targeting signaling pathways that increase sensitivity to conventional treatments; Molecular pathways targeted by environmental, physiological, or infectious agents. We will present these changes to our External Advisory Committee at our May 24, 2006 Symposium. The COBRE CCRD website can be found at www.RIH-COBRE-CARES.org. It lists NCRR funding for this Center.