LSU DENTAL COBRE: DEVELOPMENT OF NEW ADHESIVE FLOURIDE-RELEASING MONOMERS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。前言：复发的龋病是导致牙体修复失败的最常见原因。释放氟化物的修复材料可以减少修复边缘的复发龋齿。然而，目前的牙科复合材料和复合体具有较低的氟化物释放和充电能力，它们需要粘结剂才能结合到牙齿结构上。目前的牙科粘结剂也几乎没有氟化物的释放和再充电能力，并且形成了阻碍氟化物运输的屏障。封闭剂已经被用来填充后牙的凹陷和裂隙，但目前的封闭剂要么释放很少的氟化物，要么粘附性差。该项目的目标是开发新型氟化物释放型牙科粘接剂和密封剂。我们推测，由于氟的交换能力，新型释氟牙科粘结剂和封闭剂将直接将氟化物释放到牙齿结构中，改善粘结，并促进氟化物从释氟剂和复合体或主题氟化物向牙齿结构的传输。因此，它们可以显著减少龋病复发，延长修复体的寿命。以下是第一年的进展情况。目的：合成新型粘附性螯合单体和氟离子交换络合物。接受培训成为独立研究人员，并获得R01拨款。方法：与指导团队合作，参加Cobre培训计划，建立新的实验室，聘请和培训研究助理。结果：成功合成了4种新型胶粘剂螯合单体。这些单体可以形成稳定的三元金属氟化物(F-交换)络合物，可溶于混合水-有机溶剂。其中三种单体酸度高，可用于自酸蚀底漆(粘结剂)，一种可用于粘合剂和密封剂，具有较强的氟离子交换能力。讨论：这些初步结果为下一年的S研究和未来R01的应用奠定了重要基础。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Recurrent caries is the most frequent cause for the failure of dental restorations. Fluoride-releasing restorative materials can reduce recurrent caries at the restoration margins. However, current dental composites and compomers have low fluoride release and recharge capabilities and they require bonding agents to bond to the tooth structure. Current dental bonding agents also have little fluoride-releasing and recharging capabilities and form a barrier hindering the transport of fluoride. Sealants have been used to fill the pits and fissures in posterior teeth but current sealants either release little fluoride or have poor adhesion. The goal of this project is to develop new fluoride-releasing dental bonding adhesives and sealants. We hypothesize that new fluoride-releasing dental bonding adhesives and sealants will release fluoride directly into the tooth structure, improve bonding, and facilitate the transport of fluoride from fluoride-releasing compomers and composites or topic fluoride agents to the tooth structure due to the fluoride?exchange capability. Therefore, they can significantly reduce the recurrent caries and prolong the life of the restoration. The following is the progress in year1. Objective: To synthesize new adhesive chelating monomers and F-exchange chelates. To be trained to become independent researcher and to obtain a R01 grant. Methods: Worked with the mentoring team, attended the COBRE training program, set up a new laboratory, hired and trained research associates. Results: Four new adhesive chelating monomers have been successfully synthesized. These monomers can form stable ternary metal fluoride (F-exchange) chelates that are soluble in mixed water?organic solvents. Three of the monomers may be used in self-etching primer (bonding agents) due to their high acidity, and one of them may be used in adhesives and sealants due to its high fluoride-exchange capability. Discussion: These preliminary results have laid an important foundation for the next year?s study and the future R01 application.