CORE A: ADMINISTRATIVE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。管理核心(核心A)的目标是就调查范围和重点提供建议；招募、指导和促进受训人员；管理和有效利用所有资源；促进与其他科布雷、州和国家项目的富有成效的互动。我们的内部咨询委员会已得到加强，包括奥尔特博士、希梅尔法布博士、弗里塞尔博士、威尔第博士、诺尔斯博士、林德纳博士和普鲁多夫斯基博士。对于受训者，这提供了以下指导关系：Wang Prudovsky&Wojchowski；Yoon，Frisel&Lindner；Oxburgh，Himmelfarb&Wojchowski；De Vries，Knowles&Ault；Mills，Frisel，Ault&Knowles。IAC和实习生务虚会分别于7/05、11/05和3/06举行。受训者陈述了结果和目标，并完成了与导师的会议。我们的外部咨询委员会已得到加强，包括N.speck(达特茅斯大学)、P.Besmer(斯隆·凯特林大学)、G.Sprangrude(犹他州大学)和H.Broxmeyer(印第安纳大学)。L.Zon博士(HMS)也加入了我们的科学咨询委员会。一次包罗万象的静修计划在每年的初秋举行。核心A资源(连同平行学院的资金)赞助了一系列优秀的研讨会。[G.Dressler(密歇根大学)，E.Bottinger(西奈山)，T.T.Tenzen(哈佛大学)，W.Wu(Dan-Farber)，T.Gridley(杰克逊实验室)，V.Rosen(哈佛大学)，C.Mendelsohn(哥伦比亚大学)，J.Bonaventre(布里格姆与妇女医院)，J.Kreidberg(儿童医院)，D.Scadden(MGH)]。DM Wojchowski博士将继续在制定这一计划方面发挥主导作用。Joe Verdi还将为Core A贡献30%的努力。总的来说，Core A的目标是(通过专家、资深人士和国家的投入)实现以下任务：1/以临床相关的方式科学地推进我们的领域；以及2/作为有竞争力的独立调查人员来提升受训人员。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Goals of Administrative Core (Core A) are to advise on investigatory scope and focus; to recruit, mentor and advance trainees; to manage and effectively utilize all resources; and to facilitate productive interactions with other COBRE, State, and National programs. Our Internal Advisory Committee has been bolstered to include Drs. Ault, Himmelfarb, Friesel, Verdi, Knowles, Lindner and Prudovsky. For trainees, this provides the following mentoring relationships: Wang, Prudovsky & Wojchowski; Yoon, Friesel & Lindner; Oxburgh, Himmelfarb & Wojchowski; de Vries, Knowles & Ault; Mills, Friesel, Ault, & Knowles. IAC and trainee retreats were held 7/05, 11/05, and 3/06. Trainees presented findings and goals, and meeting with mentors were completed. Our External Advisory Committee has been fortified to include N.Speck (Dartmouth), P.Besmer (Sloan Kettering), G.Sprangrude (U Utah), and H.Broxmeyer (Indiana U). Dr L.Zon (HMS) also has joined our Scientific Advisory Board. An all-inclusive retreat is scheduled annually for early Fall. Core A resources (together with parallel Institute dollars) sponsor an excellent seminar series. [G.Dressler (U Michigan), E.Bottinger (Mt Sinai), T.Tenzen (Harvard), W.Wu (Dan-Farber), T.Gridley (Jackson Lab), V.Rosen (Harvard), C.Mendelsohn (Columbia), J.Bonaventre (Brigham &Women's), J.Kreidberg (Children's Hospital), D.Scadden (MGH)]. Dr. DM Wojchowski will continue to take a lead role in developing this program. Joe Verdi also will contribute 30% effort to Core A. Overall, Core A aims to enable (via expert senior and national input) the tasks of: 1/ scientifically advancing our field (in clinically relevant ways); and 2/ advancing trainees as competitive independent investigators.