GROUP VIA PHOSPHOLIPASE A2 IN ENDOPLASMIC RETICULUM STRESS INDUCED APOPTOSIS

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。b细胞凋亡在I型糖尿病的发展中是一个公认的过程，越来越多的证据表明ii型糖尿病的进行性b细胞功能障碍。最近的报道也表明内质网应激诱导的细胞凋亡有助于糖尿病患者的b细胞损失。这些发现表明iPLA2B参与了内质网应激诱导的细胞凋亡，这是促进糖尿病b细胞死亡的途径。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. B-cell apoptosis is a well-recognized process in the development of Type I diabetes and growing evidence suggests that the progressive b-cell dysfunction in TypeII diabetes. Recent reports also indicated that ER stress-induced apoptosis contributes to B-cell loss in diabetes. These findings indicate that iPLA2B participates in ER-stress induced apoptosis, a pathway that promotes b-cell death in diabetes.