MECHANISMS OF PATHOGENESIS AND RECOVERY FROM FRIEND MURINE LEUKEMIA VIRUS

逆转录病毒感染诱导白血病的康复机制 已经在Friend小鼠白血病病毒系统中进行了研究。病毒式传播 Friend病毒辅助成分和缺陷成分中的基因 已对复合体进行了检查，以确定它们在 红白血病的发生和康复。此外，主机 影响抗病毒免疫反应的基因包括 主要组织相容性复合体(H-2A、E、D和T)和非MHC基因 如Rfv-3等也进行了研究，以确定 消除病毒和白血病细胞。 在该项目的另一个方面，逆转录病毒引起的脑部疾病 使用来自Friend小鼠的多嗜性逆转录病毒进行了研究 白血病病毒。这项工作主要集中在细胞的分析上 病毒感染的特异性和所产生的病理 中枢神经系统。此外，世界不同地区的作用 病毒包膜基因在介导性疾病中的研究已经用详细的 测绘研究。

Mechanisms of recovery from leukemia induced by retroviral infection have been studied in the Friend murine leukemia virus system. Viral genes in both the helper and defective components of Friend virus complex have been examined to determine their respective roles in generation of and recovery from erythroleukemia . In addition, host genes influencing the anti-viral immune response including those in the major histocompatibility complex (H-2A, E, D, and T) and non-MHC genes such as Rfv-3 have also been studied to identify the mechanisms of elimination of both virus and leukemia cells. In a separate aspect of the project retrovirus-induced brain disease has been studied using polytropic retroviruses derived from Friend murine leukemia virus. This work has focused on analysis of the cell specificity of virus infection and the pathology produced in the central nervous system. Furthermore, the role of various regions of the viral envelope gene in mediating disease has been studied using detailed mapping studies.