THE MULTIPLE ENDOCRINE NEOPLASIA TYPE I (MEN1) TUMOR SUPPRESSOR

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。多发性内分泌瘤型（MEN）是一种常染色体显性恶性肿瘤，以内分泌组织肿瘤为特征。这种恶性肿瘤的遗传机制与Menin肿瘤抑制因子的突变有关。尽管有大量的基因数据支持Menin？虽然Menin在MEN1疾病中的作用，但其生化功能尚不清楚。然而，最近的研究表明，Menin的肿瘤抑制功能在于它能够抑制一些促进生长的转录因子的转录活性，包括JunD， Smad3和

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Multiple Endocrine Neoplasia Type (MEN) is an automsomal dominant malignancy that is characterized by tumors of endocrine tissues. The genetic mechanism responsible for this malignancy has been linked to mutations of the Menin tumor suppressor. Despite the wealth of genetic data that support Menin?s role in MEN1 disease, the biochemical function of Menin is still unknown. However, recent studies have demonstrated that the tumor suppressor function of Menin resides in its ability to repress the transcriptional activity of a number of growth-promoting transcription factors, including JunD, Smad3 and