Novel Strategies for Natural Products Synthesis

描述（由申请人提供）：该计划的目标是定义生物活性分子合成的新策略和方法。我们构建的小分子可以提供研究生物过程的工具，并最终可能用于开发新的治疗方法。这些研究也将导致更好地了解有机官能团的反应性。具体而言，我们打算开发一种合成二倍半萜化合物新芒果酚C和芒果酚A的一般策略。这些化合物具有抗肿瘤、抗菌和抗炎特性。我们还提出了一种新的碘介导的五环化反应，将被应用于一系列白藜芦醇衍生的天然产物的合成。我们预计，这些新的方法的发展，五环化将简化复杂分子的合成。天然产物的全合成推动了新方法和策略的发展。反过来，这些新的发展将被应用于其他生物和结构感兴趣的分子的合成。这些贡献将通过提供综合基础来帮助人类医学和化学生物学的进步。 公共卫生相关性：寻找新的和更有效的方法来构建小分子是一个重要的追求，这将为化学生物学和医学提供新的工具，并导致人类健康的改善。我们的目标是开发新的策略和方法，有效地构建具有药物重要性和天然产物的小分子。在这方面，我们对使用过渡金属的新的五元环形成反应特别感兴趣。

DESCRIPTION (provided by applicant): The goal of this program is to define new strategies and methods for the synthesis of bioactive molecules. The small molecules that we construct can provide tools to study biological processes and may ultimately be used to develop new therapeutics. These studies will also lead to a better understanding of organic functional group reactivity. Specifically, we intend to develop a general strategy for the synthesis of the sesterterpene compounds neomangicol C and mangicol A. These compounds possess antitumor, antibacterial and anti-inflammatory properties. We also present a novel iodine-mediated pentannulation reaction that will be applied to the synthesis of a series of resveratrol-derived natural products. It is our anticipation that these new methodological developments for pentannulation will streamline the synthesis of complex molecules. The total synthesis of the natural products drives the development of new methods and strategies. In turn, these new developments will be applied to the synthesis of other molecules of biological and structural interest. These contributions will aid advances in human medicine and chemical biology by providing a synthesis foundation. PUBLIC HEALTH RELEVANCE: Finding new and more efficient ways to construct small molecules is an important pursuit that will provide new tools for chemical biology and medicine and lead to improvements in human health. Our goals are to develop new strategies and methods that efficiently build small molecules that are of pharmaceutical importance and natural products. In this regard, we are especially interested in new five-membered ring forming reactions using transition metals.