Translational Cancer Biology Training Program

描述（由申请人提供）：本申请旨在为马萨诸塞大学医学院（UMMS）的一个新的癌症生物学培训项目寻求资金，该项目将支持六名博士后和两名博士预科学员，他们致力于癌症研究事业。该项目将以UMMS癌症生物学系为基地，但它将包括来自多个基础科学和临床部门的教师。参与该项目的教师是根据他们的科学成就和在癌症研究方面的资助记录，对转化癌症研究的欣赏以及他们指导学员的经验而选择的。这个跨部门项目的主要目的是为受训者（其中大多数将是基础科学家）提供对转化癌症研究的欣赏，以及与临床医生有效互动的能力，这将影响和指导他们的职业生涯。三个关键的发展证实了UMMS对癌症的承诺，并证明了我们要求开展培训计划的理由。医学院于2002年成立了癌症生物学系，并从耶鲁大学聘请Dario Altieri博士担任其创始主席。其次，Altieri博士还被任命为马萨诸塞大学癌症中心主任，负责扩大和增强该中心的影响力。最后，在生物医学科学研究生院的主持下，形成了一个新的跨部门癌症生物学研究生课程。正如下面将更详细地讨论的那样，所有这三种努力是紧密结合在一起的。癌症生物系是癌症中心的基石，研究生课程与癌症中心的课程相关联。这些努力的首要主题是转化性癌症研究。更具体地说，他们的中心任务是利用UMMS卓越的基础科学事业来进行人类癌症的临床管理，反过来，使临床问题能够影响和指导基础科学。从本质上讲，这些是翻译研究的定义原则。这种方法及其实施所产生的基础设施为培养研究生和博士后提供了良好的环境。事实上，拟议的培训计划是我们癌症使命的关键组成部分，它基于我们的转化和跨部门癌症研究理念。

DESCRIPTION (provided by applicant): This application seeks funding of a new training program in Cancer Biology at the University of Massachusetts Medical School (UMMS) that will support six post-doctoral and two pre-doctoral trainees who are committed to careers in cancer research. The program will be based in the Department of Cancer Biology at UMMS but it will include faculty from multiple basic science and clinical departments. Faculty have been selected for participation in this program based on their scientific achievements and track record of funding in cancer research, appreciation for translational cancer research and their experience in mentoring trainees. A major intent of this inter-departmental program is to provide the trainees, most of whom will be basic scientists, with an appreciation for translational cancer research and with the ability to interact effectively with clinicians that will influence and guide their careers. Three key developments substantiate the commitment of UMMS to cancer and justify our request for a training program. The medical school established a Department of Cancer Biology in 2002 and recruited Dr. Dario Altieri from Yale to be its founding Chair. Second, Dr. Altieri was also named Director of the UMass Cancer Center and charged with expanding and enhancing the impact of this center. Lastly, a new graduate program in cancer biology was formed that is inter-departmental under the auspices of the Graduate School of Biomedical Sciences. As will be discussed in more detail below, all three of these endeavors are closely integrated. The Department of Cancer Biology is a cornerstone of the Cancer Center, and the graduate program is linked to the programs of the Cancer Center. The overarching theme of these endeavors is translational cancer research. More specifically, their central mission is to harness the extraordinary basic science enterprise that exists at UMMS to the clinical management of human cancers and, conversely, to enable clinical problems to influence and guide basic science. In essence, these are the defining principles of translational research. This approach and the infrastructure that has resulted from its implementation provide an outstanding environment for the training of graduate students and post-doctoral fellows. Indeed, the proposed training program is a critical component of our cancer mission and it is predicated on our philosophy of translational and inter-departmental cancer research.