TRAINING IN CANCER THERAPEUTICS

描述(由申请人提供)：南卡罗来纳医科大学(MUSC)和罗林斯癌症中心的这份提案请求支持为博士后研究员提供癌症治疗方面的跨学科研究培训计划。它旨在培养具有生物医学科学背景的有前途的年轻科学家，特别强调癌症的管理以及开发针对特定癌症的新疗法所需的实验战略、方法和技术。毫无疑问，未来几十年，我们对癌症治疗中涉及的分子(化学和生物)的结构和功能的理解将取得更快的进展。这些见解的成功应用将有助于开发新的治疗方法来治疗和预防癌症。这样的进步将需要训练有素、精力充沛、多产的科学家，他们有能力理解和操纵生理环境中的分子事件。这些都是我们希望通过博士后综合培训项目培养出来的人。符合导师资格的教师成员是根据他们在癌症治疗方面的研究兴趣、积极的NIH研究支持、持续的合作、成功的培训和指导经验以及对博士后培训的承诺来选择的。其中教授18人，副教授2人，助理教授4人。它们拥有强劲的出版记录和充足的资金。19人(80%)拥有NCI研究补助金。他们代表了2所学院的9个系(医学院的生物化学、生物统计学、细胞生物学、内科、微生物学、病理学、药理学和外科，以及药学院的药学)。项目主任和副主任由一个项目指导委员会和一个由小分子和基因治疗领域的杰出专家组成的外部咨询委员会提供协助。培训计划的关键组成部分是指导研究经验、提供癌症广泛视角的必修课、负责任地进行研究的必要培训、选修课、期刊俱乐部、研讨会、在地区和国家会议上的陈述以及专业发展活动。方案评估是培训方案的强项。

DESCRIPTION (provided by applicant): This proposal from the Medical University of South Carolina (MUSC) and the Rollings Cancer Center requests support for an interdisciplinary research training program in cancer therapeutics for postdoctoral fellows. It is designed to train promising young scientists with backgrounds in the biomedical sciences with special emphasis on the management of cancer and the experimental strategies, approaches, and technologies necessary to develop novel therapeutics targeting specific cancers. Future decades will undoubtedly see even more rapid advances in our understanding of the structure and function of molecules (both chemical and biological) involved in cancer therapy. Successful application of these insights will permit development of novel therapeutic approaches to the treatment and prevention of cancer. Such advances will require well-trained, energetic, and productive scientists with the ability to understand and manipulate molecular events within a physiological context. These are the type of individuals we aim to develop through the integrated postdoctoral components of this training program. The Mentor-eligible Faculty Members were selected based on their research interests related to cancer therapeutics, active NIH research support, ongoing collaborations, successful training and mentoring experience, and commitment to postdoctoral training. The 24 members include 18 professors, 2 associate professors, and 4 assistant professors. They have strong publication records and are well funded. Nineteen (80%) hold NCI research grants. They represent 9 departments in 2 colleges (Biochemistry, Biostatistics, Cell Biology, Medicine, Microbiology, Pathology, Pharmacology, and Surgery in the College of Medicine, and Pharmaceutical Sciences in the College of Pharmacy). The Program Director and co-Director are assisted by a Program Steering Committee and an External Advisory Committee of outstanding experts in the field of small molecule and gene therapy. Key components of the training program are the mentored research experience, a required course providing a broad perspective of cancer, required training in responsible conduct of research, elective courses, journal clubs, seminars, presentations at regional and national conferences, and professional development activities. Program evaluation is a strength of the training program.