Ligand Recognition & Molecular Gating 2008 Gordon Research Conference

描述(由申请人提供)：该提案请求部分支持将于2008年3月2日至7日在加利福尼亚州文图拉举行的关于配基识别和分子门控的国际会议，作为戈登研究会议系列的一部分。会议的广泛和长期目标是增加我们对完整的膜蛋白如何结合配体(离子、小分子、蛋白质)和跨膜传递信号的理解。会议的重点是离子通道、G蛋白偶联受体和所有类型的转运蛋白，重点是将高分辨率结构数据与功能和理论数据相结合，以探索这些蛋白质的门控或由配体激活。这次会议的具体目标是召集大约40名代表膜蛋白研究关键领域的发言者，总共150名与会者，在一个相对孤立的环境中举行为期五天的会议。该计划将有一个主题演讲和八个会议，广泛涉及核苷酸偶联转运体；离子、小分子和糖的转运体；配基和电压门控离子通道，G蛋白偶联受体中的配基识别；脂类对蛋白质折叠和功能的影响；以及获得膜蛋白质结构信息的新方法。这项申请的意义在于，配基识别和分子门控戈登研究会议是推动国际膜蛋白质结构/功能研究人员研究的一系列会议的关键组成部分。这一应用的与健康相关的是，目前超过50%的药物靶标是本次会议讨论的类型的完整膜蛋白，其结构和功能描述与新化疗药物的设计直接相关。生物化学家、生物物理学家、结构生物学家和理论家对新结果的介绍和讨论将确定该领域需要实验解决的问题，影响领域包括癌症(ABC转运体)、视力/抑郁/心血管疾病(G蛋白偶联受体)和神经疾病(离子通道)。公共卫生相关性：这一应用的健康相关性是，目前超过50%的药物靶标是本次会议讨论的类型的完整膜蛋白，其结构和功能描述与新化疗药物的设计直接相关。生物化学家、生物物理学家、结构生物学家和理论家对新结果的介绍和讨论将确定该领域需要实验解决的问题，影响领域包括癌症(ABC转运体)、视力/抑郁/心血管疾病(G蛋白偶联受体)和神经疾病(离子通道)。

DESCRIPTION (provided by applicant): This proposal requests partial support for an international meeting on Ligand Recognition and Molecular Gating as part of the Gordon Research Conference series to be held in Ventura, CA, March 2-7, 2008. The broad and long term goal of the conference is to increase our understanding of how integral membrane proteins bind ligands (ions, small molecules, proteins) and transmit signals across membranes. The conference focuses on ion channels, G-protein coupled receptors, and transporters of all types, with emphasis on combining high resolution structural data with functional and theoretical data to probe gating or activation by ligands of these proteins. The specific aims of this meeting will be to convene approximately 40 speakers that represent critical areas of membrane protein research with a total of 150 participants for a five day conference in a relatively isolated setting. The program will have a keynote address and eight sessions that broadly address nucleotide-coupled transporters; transporters of ions, small molecules and sugars; ligand- and voltage-gated ion channels, ligand recognition in G-protein coupled receptors; the influence of lipids on protein folding and function; and new methods for obtaining structural information on membrane proteins. The significance of this application is that the Gordon Research Conference on Ligand Recognition and Molecular Gating is a critical component of the series of conferences that drive research in the international community of membrane protein structure/function researchers. The health relatedness of this application is that well over 50% of current pharmaceutical targets are integral membrane proteins of the types discussed at this conference, with structural and functional descriptions directly relevant to the design of new chemotherapeutic agents. The presentation and discussion of new results among biochemists, biophysicists, structural biologists, and theoreticians will define the questions that require experimental resolution in this field, impacting areas such as cancer (ABC transporters), vision/depression/cardiovascular diseases (G- protein coupled receptors), and neurological diseases (ion channels). PUBLIC HEALTH RELEVANCE: The health relatedness of this application is that well over 50% of current pharmaceutical targets are integral membrane proteins of the types discussed at this conference, with structural and functional descriptions directly relevant to the design of new chemotherapeutic agents. The presentation and discussion of new results among biochemists, biophysicists, structural biologists, and theoreticians will define the questions that require experimental resolution in this field, impacting areas such as cancer (ABC transporters), vision/ depression/ cardiovascular diseases (G-protein coupled receptors), and neurological diseases (ion channels).