Recruitment and Assessment Core Patient Recruitment

CCNMD的这个招聘和评估(R&A)核心的目标是支持所有 中心的项目。R&A的主要目标有七个：1)实施良好的筛查， CCNMD项目的招募和评估程序；2)招募老年人和年轻人(&gt；60岁) 每年符合CCNMD项目入选标准的患者；3)招募和筛选正常患者， CCNMD项目需要年龄匹配的年轻志愿者；4)保持质量控制 监控考核核心人员工作可靠性的制度；5)进行标准化核磁共振检查 用于患者评估和采集血液进行基因分析的研究；6)将患者分配到 不同的项目，并确保不会给学科带来不必要的负担；以及7)开发和 维护尸检资源。 研发核心将主要通过训练有素的关键人员和研究人员来实现这些目标， 包括研究精神病学家、神经心理学家、研究助理、神经心理学 技术员、神经病理学家和尸检协调员。受试者将接受一次彻底的 精神病学评估，医学评估，心血管和 脑血管危险因素、标准化的神经学检查和标准化的认知 评估包括一组全面的神经心理测试。 将通过各种来源招募患者，包括杜克大学的不耐烦服务和 州立医院、杜克附属诊所、杜克ECT服务、临床试验和NIMH赞助的 抑郁症的自然主义纵向研究。老年人控制将通过Aging获得 老年志愿者登记中心。将通过类似的数据库招募年轻的控制组。 研发人员将努力确保所有受试者都完成了CCNMD方案。研发人员将 为抑郁的受试者找到适当的跟进，无论是通过转介还是参加其他 研究性研究。

The objective of this Recruitment and Assessment (R&A) Core for the CCNMD is to support all of the Center's projects. There are seven main aims of R&A: 1) To implement a well functioning screening, recruitment and assessment process for CCNMD projects; 2) To recruit elderly and young (> 60 yrs) patients meeting entry criteria per year for CCNMD projects; 3) To recruit and screen the normal, age-matched and young volunteers required for CCNMD projects; 4) To maintain a quality control system to monitor the work of the assessment core staff for reliability; 5) To conduct standardized MRI studies for patient assessment and to collect blood for genetic analyses; 6) Allocation of patients to different projects and ensuring that there is no undue burden on subjects; and 7) To develop and maintain an autopsy resource. The R&A Core will meet these goals chiefly through highly trained key personnel and research staff, including research psychiatrists, neuropsychologist, research assistants, a neuropsychological technician, a neuropathologist, and an Autopsy Coordinator. Subjects will receive a thorough psychiatric assessment, medical assessment, a detailed review of cardiovascular and cerebrovascular risk factors, standardized neurological examination, and a standardized cognitive assessment including a comprehensive neuropsychological test battery. Patients will be recruited through a variety of sources, including the impatient service at Duke and a state hospital, Duke affiliated clinics, the Duke ECT services, clinical trials, and an NIMH-sponsored naturalistic longitudinal study of depression. Elderly controls will be obtained through an Aging Center Registry of elderly volunteers. Young controls will be recruited through a similar data base. The R&A staff will work to ensure that all subjects have completed CCNMD protocols. R&A staff will find appropriate follow-up for depressed subjects, either through referral or enrollment in other research studies.