Consortium for Neuropsychiatric Phenomics-Coordinating Center (1 of 8)

神经精神表型组学联盟（CNP）通过组装 一个跨学科的研究团队，以解决行为研究中尚未解决的主要挑战 紊乱CNP利用了表型组学的新学科-人类表型的系统研究 在全基因组水平上--通过整合基础科学、临床科学和信息科学。神经精神障碍 有巨大的公共卫生意义，目前有一个基本的和 用于研究这些疾病的临床研究策略。CNP打破了人为的界限 通过研究不同诊断中重要的脑相关表型， 并在同一项目中结合基础和临床科学。CNP进一步侧重于 开发新的分析工具，在全基因组范围内研究复杂的多变量表型， 信息学方法的图形可视化，表示和测试的多层次 从基因组到综合征的跨学科假设。CNP包括8个 该小组由来自不同学科的52名调查员组成。CNP团队将执行 由两个P30核心和U 54协调中心支持的五个互锁R 01项目。U54 包括：（1）一个行政小组;（2）一个执行运营团队，将合作完成 全联盟范围内的日常规划、预算管理和评估活动，以确保 研究项目和核心之间的整合;（3）指导委员会，每年两次审查 （4）在关键战略方向和资源分配方面取得进展并进行有约束力的表决; 咨询委员会提供年度评价审查，通过向秘书长提出建议指导业绩， 指导委员会和执行业务小组。互动和创新将进一步促进， 邀请外部专家参加的年度务虚会;一系列其他知识共享活动;以及 概念试点项目方案。U 54小组还将管理数据共享和传播活动 确保CNP的概念和数据产品作为一种免费的 国际研究界的资源。

The Consortium for Neuropsychiatric Phenomics (CNP) advances the NIH Roadmap Initiative by assembling an interdisciplinary research team to address major unsolved challenges in research on behavioral disorders. The CNP leverages the newdiscipline of phenomics - the systematic study of human phenotypes on a genome-wide level - by integrating basic, clinical and information sciences. Neuropsychiatric disorders have enormous public health significance, and there is currently a broad chasm between the basic and clinical research strategies used to study these disorders. The CNP breaks down artificial boundaries between psychiatric syndromes by studying important brain-relevant phenotypes across different diagnoses, and by combining basic and clinical sciences within the same projects. The CNP further focuses on developing novel analytic tools to study complex multivariate phenotypes on a genome-wide scale, and informatics approaches for the graphical visualization, representation and testing of multi-level interdisciplinary hypotheses spanning concepts from genome to syndrome. The CNP comprises 8 components led by a team of 52 investigators representing diverse disciplines. The CNP team will execute five interlocking R01 projects supported by two P30 cores and this U54 Coordinating Center. The U54 comprises: (1) an Administrative Group; (2) an Executive Operations Team that will collaboratively complete day-to-day consortium-wide planning, budget management, and evaluation activities to assure optimal integration among the research projects and cores; (3) the Steering Committee for twice-yearly reviews of progress and binding votes on critical strategic directions and resources allocations; and (4) an External Advisory Board to provide annual evaluative review, guiding performance through recommendations to the Steering Committee and Executive Operations Team. Interaction and innovation will be further promoted by annual retreats with invited external experts; a series of other knowledge-sharing activities; and a proof-of- concept pilot project program. The U54 team will also manage data sharing and dissemination activities consortium-wide, ensuring that the conceptual and data products of the CNP are freely available as a resource to the international research community.