BEHAVIORAL PHARMACOLOGY OF ALCOHOL

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该项目侧重于过量饮酒的猴子模型，以直接解决酒精滥用和酒精中毒的风险和后果问题。 风险因素包括遗传易感性、对环境或药物挑战的应激反应、年龄和性别（包括月经周期）。 其后果包括器官组织损伤、与组织损伤相关的基因表达改变、睡眠障碍、昼夜节律改变、月经周期障碍、脑容量结构变化和HPA轴中断。 我们还将一个物种的比较，通过测量恒河猴（猕猴）和食蟹猴（食蟹猴）的乙醇消耗量的设计。 该方法很像一项人口研究，其中所有人都暴露于相同的饮用乙醇的介绍，然后允许至少1年的自由选择饮用乙醇（4% w/v）或水沿着三餐/天。 课程持续时间为22小时，每周7天。 允许获取乙醇和记录饮酒数据的计算机控制设备非常敏感和可靠，但需要一致的环境，例如ONPRC的住房。 该项目将利用内分泌学核心，成像核心，遗传研究和信息学计划。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project focuses on monkey models of excessive alcohol consumption to directly address questions of risk for and consequences of alcohol abuse and alcoholism. The risk factors include genetic predisposition, stress response to environmental or pharmacological challenge, age, and sex (including menstrual cycle phase). Consequences include organ tissue damage, alterations in gene expression related to tissue damage, sleep disturbances, alterations in circadian rhythms, menstrual cycle impairments, structural changes in brain volume, and HPA axis disruptions. We also incorporate a species comparison into the designs by measuring ethanol consumption in both rhesus (macaca mulatta) and cynomolgus (macaca fascicularis) macaques. The approach is much like a population study, where individuals are all exposed to the same introduction to drinking ethanol and then are allow at least 1 year of a free choice between drinking ethanol (4% w/v) or water along with 3 meals/day. Sessions are 22 hr duration and are given 7 days/week. The computer controlled equipment that allows access to ethanol and records drinking data is very sensitive and reliable, but require a consistent environment, such as the housing rooms at ONPRC. This project will make use of the endocrinology core, the imaging core, and the genetic research and informatics program.